Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 11/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TACR3 | P29371 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2951055 | 0.79 | SLC6A4 (1.00) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL3026559 | 0.79 | CYP2C9 (0.67) | CYP2C9CYP2C19HTR2BMAPK14LMNA | |
| SCHEMBL2952322 | 0.78 | SLC6A4 (0.79) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL10445779 | 0.78 | KDM4E (0.46) | LMNAGAATACR3 | |
| Hydrochloric Acid SCHEMBL9247465 | 0.77 | KDM4E (0.48) | LMNAGAATACR3 | |
| SCHEMBL6658178 | 0.76 | SLC6A4 (0.81) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL588656 | 0.76 | SLC6A4 (0.81) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL5543652 | 0.76 | SLC6A4 (0.81) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL588544 | 0.76 | SLC6A4 (0.81) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL12089894 | 0.76 | SLC6A4 (0.71) | SLC6A4SLC6A3SLC6A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5441967-A | Treating cerebral edema; anticholinesterase or brain function-improving agent | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-08-15 | — | — | US | disclosed |
| EP-0378207-B1 | CYCLIC AMINE COMPOUNDS AND THEIR USE | Takeda Chemical Industries, Ltd. (JP) | 1993-09-22 | — | — | EP | disclosed |
| US-5177087-A | Cerebral edema, cholinesterase inhibitor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| EP-0378207-A1 | Cyclic amine compounds and their use | Takeda Chemical Industries, Ltd. (JP) | 1990-07-18 | — | — | EP | disclosed |