SCHEMBL9255699

SCHEMBL9255699

CC(=O)N=c1sc(C)cn1-c1ccc(F)c(C(F)(F)F)c1

nearest known ligand 0.39

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
AR P10275 13/20 0.39
NOTUM Q6P988 1/20 0.38
RXRA P19793 1/20 0.37
GRIN1 Q05586 1/20 0.37
GRIN2B Q13224 1/20 0.37
ACACB O00763 1/20 0.35
RAB9A P51151 1/20 0.34
CNR2 P34972 1/20 0.34
CFTR P13569 1/20 0.34
LMNA P02545 1/20 0.34
TP53 P04637 1/20 0.34
MAPT P10636 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9253747 0.89 AR (0.38) ARNOTUMRXRAGRIN1GRIN2B
SCHEMBL8424212 0.87 AR (0.37) ARNOTUMRXRAGRIN1GRIN2B
SCHEMBL8425518 0.86 AR (0.36) ARNOTUMRXRAGRIN1GRIN2B
SCHEMBL9085276 0.86 AR (0.36) ARNOTUMRXRAGRIN1GRIN2B
SCHEMBL8424637 0.85 AR (0.36) ARNOTUMRXRAGRIN1GRIN2B
SCHEMBL15405272 0.82 CNR2 (0.40) RAB9ACNR2MAPT
SCHEMBL9064537 0.80 CNR2 (0.49) NOTUMCNR2MAPT
SCHEMBL2871234 0.79 ALDH1A1 (0.37) NOTUMRAB9ACNR2
SCHEMBL2871238 0.79 ALDH1A1 (0.37) NOTUMRAB9ACNR2
SCHEMBL2873122 0.77 KMT2A (0.40) NOTUMRAB9ALMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-5186444-A None JP disclosed
US-5459277-A Iminothiazolines, their production and use as herbicides, and intermediates for their production SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1995-10-17 US disclosed
US-5350736-A Iminothiazolines, their production and use as herbicides, and intermediates for their production SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-09-27 US disclosed
JP-H05186444-A IMINOTHIAZOLINE, HERBICIDE USING THE SAME AS ACTIVE COMPONENT AND ITS PRODUCTIVE INTERMEDIATE SUMITOMO CHEM CO LTD 1993-07-27 JP disclosed
EP-0529482-A1 Iminothiazolines, their production and use as herbicides, and intermediates for their production SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1993-03-03 EP disclosed