SCHEMBL8424637

SCHEMBL8424637

Cc1cn(-c2ccc(F)c(C(F)(F)F)c2)c(=NC(=O)C(F)Cl)s1

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
AR P10275 13/20 0.36
NOTUM Q6P988 1/20 0.35
RXRA P19793 3/20 0.34
GRIN1 Q05586 3/20 0.34
GRIN2B Q13224 3/20 0.34
USP2 O75604 1/20 0.33
POLB P06746 1/20 0.33
ACACB O00763 1/20 0.33
CCR2 P41597 1/20 0.32
CCR5 P51681 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8424212 0.91 AR (0.37) ARNOTUMRXRAGRIN1GRIN2B
SCHEMBL8425518 0.90 AR (0.36) ARNOTUMRXRAGRIN1GRIN2B
SCHEMBL9085276 0.88 AR (0.36) ARNOTUMRXRAGRIN1GRIN2B
SCHEMBL9255699 0.85 AR (0.39) ARNOTUMRXRAGRIN1GRIN2B
SCHEMBL9253747 0.84 AR (0.38) ARNOTUMRXRAGRIN1GRIN2B
SCHEMBL8428409 0.82 CNR2 (0.43) NOTUMPOLB
SCHEMBL8428107 0.81 PKM (0.37) NOTUMPOLB
SCHEMBL8423732 0.81 USP2 (0.34) USP2POLB
SCHEMBL8424571 0.78 CNR1 (0.38) NOTUMRXRAGRIN1GRIN2BPOLB
SCHEMBL8425765 0.76 RAB9A (0.40) RXRAGRIN1GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0636616-B1 Process for production of fluoroalkanecarboxamide derivatives SUMITOMO CHEMICAL CO (JP) 1999-10-27 EP disclosed
US-5484933-A Process for production of fluoroalkane carboxamide derivatives SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-01-16 US disclosed
EP-0636616-A1 Process for production of fluoroalkanecarboxamide derivatives SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-02-01 EP disclosed