Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | RARA | P10276 | 1/20 | 0.45 |
| ▸ | RARB | P10826 | 1/20 | 0.45 |
| ▸ | RARG | P13631 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8031197 | 0.80 | CA12 (0.49) | PARP1RARARARBRARGCA12 | |
| SCHEMBL5222285 | 0.78 | CA12 (0.48) | PARP1RARARARBRARGCA12 | |
| SCHEMBL2962800 | 0.77 | CYP1A2 (0.70) | CA12CA1CA2CA7CA9 | |
| SCHEMBL9259002 | 0.77 | CYP1A2 (0.49) | PARP1RARARARBRARGCA12 | |
| SCHEMBL22939960 | 0.76 | CYP1A2 (0.59) | HPGDKDM4EALDH1A1MAPTCYP1A2 | |
| SCHEMBL5217933 | 0.76 | HPGD (0.56) | CA12CA1CA2ESR1CA7 | |
| SCHEMBL24595883 | 0.75 | NPC1 (0.54) | PARP1RARARARBRARGCA12 | |
| SCHEMBL24345242 | 0.75 | CTSS (0.51) | CTSSHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL5556244 | 0.75 | CA12 (0.66) | RARARARBRARGCA12CA1 | |
| SCHEMBL2997892 | 0.74 | CA12 (0.56) | CA12CA1CA2ESR1CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428160-A | Condensation of imidazole derivative with cyano- or halo-substituted benzene derivative containing leaving group esterified with carboxylic or sulfonic acid | CIBA-GEIGY CORPORATION (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0165904-B1 | SUBSTITUTED BICYCLE COMPOUNDS | CIBA-GEIGY AG (CH) | 1991-04-10 | — | — | EP | disclosed |
| US-4889861-A | Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors | CIBA-GEIGY CORP. (US) | 1989-12-26 | — | — | US | disclosed |
| EP-0114573-B1 | IMIDAZO(1,5-A)PYRIDINE DERIVATIVES | CIBA-GEIGY AG (CH) | 1988-04-20 | — | — | EP | disclosed |
| US-4728645-A | THROMBOXANE SYNTHETASE INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1988-03-01 | — | — | US | disclosed |
| US-4617307-A | Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors | CIBA-GEIGY CORPORATION (US) | 1986-10-14 | — | — | US | disclosed |
| US-4588732-A | Certain imidazo(1,5-a)pyridine derivatives and their use as thromboxane synthetase inhibitors | CIBA-GEIGY CORPORATION (US) | 1986-05-13 | — | — | US | disclosed |
| EP-0165904-A2 | Substituted bicycle compounds | CIBA-GEIGY AG (CH) | 1985-12-27 | — | — | EP | disclosed |