Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9258062 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2CYP2C19ALDH1A1HPGDHTT | |
| SCHEMBL7282676 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2CYP2C19ALDH1A1HPGDHTT | |
| SCHEMBL7163448 | 0.85 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1TSHRKMT2A | |
| SCHEMBL8670521 | 0.85 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1TSHRKMT2A | |
| SCHEMBL9253331 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1TSHRKMT2A | |
| SCHEMBL9264405 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1TSHRKMT2A | |
| SCHEMBL7372917 | 0.79 | CYP2C19 (0.54) | CYP2C19ALDH1A1TSHR | |
| SCHEMBL9444929 | 0.79 | CYP2C19 (0.54) | CYP2C19ALDH1A1TSHR | |
| SCHEMBL8910216 | 0.79 | CYP2C19 (0.54) | CYP2C19ALDH1A1TSHR | |
| SCHEMBL9262904 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1HTTKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5393875-A | Hypotensive, cardiotonic and antiischemic agents | HOFFMANN-LA ROCHE INC. (US) | 1995-02-28 | — | — | US | disclosed |