SCHEMBL9256673

SCHEMBL9256673

Cc1cccn2c(=O)c(-c3nnn(CC(C)C)n3)cnc12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 3/20 0.39
MAPT P10636 3/20 0.39
LMNA P02545 2/20 0.38
HDAC8 Q9BY41 1/20 0.36
ALDH1A1 P00352 3/20 0.35
HPGD P15428 1/20 0.35
CASP1 P29466 1/20 0.35
CASP7 P55210 1/20 0.35
HSD17B10 Q99714 1/20 0.35
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
TNNI3 P19429 1/20 0.34
TNNT2 P45379 1/20 0.34
TNNC1 P63316 1/20 0.34
TRPV1 Q8NER1 2/20 0.34
KDM4E B2RXH2 1/20 0.34
RECQL P46063 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
CNR1 P21554 1/20 0.34
CNR2 P34972 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9215578 0.89 MAPT (0.37) TP53MAPTLMNAHDAC8ALDH1A1
SCHEMBL9255747 0.87 TP53 (0.40) TP53MAPTLMNAHDAC8ALDH1A1
SCHEMBL9210655 0.85 TP53 (0.39) TP53MAPTLMNAALDH1A1HPGD
Hydrochloric Acid SCHEMBL9219227 0.84 TP53 (0.39) TP53MAPTLMNAALDH1A1HPGD
SCHEMBL9213292 0.83 MAPT (0.38) TP53MAPTLMNAHDAC8ALDH1A1
SCHEMBL9255403 0.83 MAPT (0.38) TP53MAPTLMNAHDAC8ALDH1A1
SCHEMBL9255180 0.83 MAPT (0.38) TP53MAPTLMNAHDAC8ALDH1A1
SCHEMBL9218231 0.82 NPC1 (0.38) TP53MAPTLMNAALDH1A1HPGD
SCHEMBL9259987 0.82 TP53 (0.50) TP53MAPTLMNAHDAC8ALDH1A1
SCHEMBL9260614 0.81 MAPT (0.40) TP53MAPTLMNAHDAC8ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5475000-A Antiulcer agents CHINOIN GYOGYSZER-ES VEGYESZETI TERMEKEK GYARA RT. (HU) 1995-12-12 US disclosed