Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.54 |
| ▸ | ACE | P12821 | 7/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | PREP | P48147 | 2/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9592654 | 0.98 | CTSL (0.54) | CTSLACEMEN1KMT2AUSP2 | |
| SCHEMBL9773233 | 0.98 | CTSL (0.54) | CTSLACEMEN1KMT2AUSP2 | |
| SCHEMBL9732240 | 0.94 | ACE (0.51) | CTSLACEMEN1KMT2AUSP2 | |
| SCHEMBL9175234 | 0.88 | ACE (0.60) | ACEMEN1KMT2AUSP2LMNA | |
| SCHEMBL9176326 | 0.88 | ACE (0.60) | ACEMEN1KMT2AUSP2LMNA | |
| SCHEMBL9170195 | 0.85 | ACE (0.64) | ACEMEN1KMT2AUSP2LMNA | |
| SCHEMBL9170201 | 0.85 | ACE (0.64) | ACEMEN1KMT2AUSP2LMNA | |
| SCHEMBL9439136 | 0.85 | ACE (0.64) | ACEMEN1KMT2AUSP2LMNA | |
| SCHEMBL10607382 | 0.85 | CTSL (0.49) | CTSLACEMEN1KMT2AUSP2 | |
| SCHEMBL4404273 | 0.85 | ACE (0.53) | CTSLACEMEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401766-A | Hypotensive agents with vasodilation | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-03-28 | — | — | US | disclosed |
| US-5162362-A | Hypotensive agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-11-10 | — | — | US | disclosed |
| US-5158959-A | Treatment of hypertension | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-10-27 | — | — | US | disclosed |