Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.67 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.67 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.67 |
| ▸ | CLK1 | P49759 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.56 |
| ▸ | MAPT | P10636 | 9/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9256871 | 1.00 | DYRK1A (0.67) | DYRK1ADYRK1BDYRK2PIK3CACLK1 | |
| SCHEMBL981312 | 0.76 | DYRK1A (0.69) | DYRK1ADYRK1BDYRK2PIK3CACLK1 | |
| SCHEMBL10896573 | 0.74 | DYRK2 (0.54) | DYRK1ADYRK1BDYRK2CLK1ALDH1A1 | |
| SCHEMBL9566898 | 0.74 | DYRK1A (1.00) | DYRK1ADYRK1BDYRK2CLK1ALDH1A1 | |
| SCHEMBL11501954 | 0.73 | ALDH1A1 (0.65) | DYRK1ADYRK1BDYRK2CLK1ALDH1A1 | |
| SCHEMBL11501952 | 0.73 | ALDH1A1 (0.65) | DYRK1ADYRK1BDYRK2CLK1ALDH1A1 | |
| SCHEMBL31237283 | 0.72 | DYRK1A (0.62) | DYRK1ADYRK1BDYRK2ALDH1A1MAPT | |
| SCHEMBL29577825 | 0.72 | DYRK1A (0.62) | DYRK1ADYRK1BDYRK2ALDH1A1MAPT | |
| SCHEMBL16656152 | 0.72 | DYRK1A (0.62) | DYRK1ADYRK1BDYRK2ALDH1A1MAPT | |
| SCHEMBL9786539 | 0.72 | DYRK1A (0.62) | DYRK1ADYRK1BDYRK2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5416224-A | Reaction of acetyldihydro-2-(3H)-furanone with aldehyde and alkali metal hydroxide | HENKEL CORPORATION (US) | 1995-05-16 | — | — | US | disclosed |