Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 20/20 | 0.75 |
| ▸ | BCHE | P06276 | 16/20 | 0.75 |
| ▸ | GRIN1 | Q05586 | 11/20 | 0.66 |
| ▸ | GRIN2A | Q12879 | 11/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9257159 | 0.89 | ACHE (0.68) | ACHEBCHEGRIN1GRIN2ACHRM1 | |
| SCHEMBL29817802 | 0.86 | BCHE (1.00) | ACHEBCHE | |
| SCHEMBL9252701 | 0.86 | MAPT (0.63) | ACHEBCHEGRIN1GRIN2ACHRM1 | |
| SCHEMBL9260660 | 0.83 | ACHE (0.54) | ACHEBCHEGRIN1GRIN2ACHRM1 | |
| SCHEMBL5990879 | 0.80 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL29817805 | 0.79 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2A | |
| SCHEMBL17992251 | 0.79 | ACHE (0.68) | ACHEBCHEGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL29817798 | 0.78 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2A | |
| SCHEMBL9258833 | 0.78 | ACHE (0.69) | ACHEBCHEGRIN1GRIN2ACHRM1 | |
| SCHEMBL8018131 | 0.78 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5391553-A | Increasing cholinergic functionin mammals | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-02-21 | — | — | US | disclosed |
| EP-0282959-A2 | Substituted 9-amino-tetrahydro-acridines and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-09-21 | — | — | EP | disclosed |