SCHEMBL9257557

SCHEMBL9257557

[O]c1cnc2cc(Cl)ccc2n1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 2/20 0.47
PIK3CG P48736 1/20 0.44
ADORA3 P0DMS8 1/20 0.43
FGFR3 P22607 1/20 0.43
KDR P35968 1/20 0.43
PDGFRB P09619 1/20 0.42
PDGFRA P16234 1/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
NR4A2 P43354 1/20 0.41
F7 P08709 1/20 0.41
F3 P13726 1/20 0.41
DYRK1A Q13627 1/20 0.41
HTT P42858 2/20 0.40
ALDH1A1 P00352 3/20 0.40
MAPT P10636 2/20 0.40
KDM4E B2RXH2 1/20 0.40
MEN1 O00255 1/20 0.40
USP2 O75604 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL346120 0.79 ALDH1A1 (0.55) HRH4PIK3CGADORA3FGFR3KDR
SCHEMBL29580471 0.79 ALDH1A1 (0.55) HRH4PIK3CGADORA3FGFR3KDR
Ammonia Solution, Strong SCHEMBL28148393 0.78 ALDH1A1 (0.53) HRH4PIK3CGADORA3FGFR3KDR
SCHEMBL30665754 0.76 HRH4 (0.47) HRH4PIK3CGADORA3FGFR3KDR
SCHEMBL2616096 0.76 HRH4 (0.55) HRH4PIK3CGADORA3FGFR3KDR
SCHEMBL4725394 0.76 PIK3CG (0.53) HRH4PIK3CGADORA3PDGFRBPDGFRA
SCHEMBL14322277 0.76 HRH4 (0.47) HRH4PIK3CGADORA3FGFR3KDR
SCHEMBL8530324 0.76 HRH4 (0.47) HRH4PIK3CGADORA3FGFR3KDR
SCHEMBL16671696 0.76 HRH4 (0.47) HRH4PIK3CGADORA3FGFR3KDR
SCHEMBL629503 0.75 ALDH1A1 (0.55) HRH4PIK3CGADORA3FGFR3KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110172472-A Tissue specific expression and hybrid plant generate 美国陶氏益农公司 2019-08-27 CN disclosed
CN-106170548-B Tissue specific expression and hybrid plant production 美国陶氏益农公司 2019-04-19 CN disclosed
CN-105859707-B (R)-N- (thiazol-2-yl) -2- [4- (quinoxaline -2- oxygroups) phenoxy group] amide derivatives and its preparation method and application 河北大学 2018-07-20 CN disclosed
CN-106170548-A Tissue specific expression and hybrid plant production 美国陶氏益农公司 2016-11-30 CN disclosed
US-5405867-A Milbemycin derivatives with insecticidal and anthelmintic properties; for plants and animals SANKYO COMPANY, LIMITED (JP) 1995-04-11 US disclosed
EP-0342710-B1 MACROLIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE Sankyo Company Limited (JP) 1993-05-19 EP disclosed
US-4963582-A ANTHELMINTICS, ACARICIDES, INSECTICIDES SANKYO COMPANY LIMITED (JP) 1990-10-16 US disclosed
EP-0342710-A1 Macrolide compounds, their preparation and their use Sankyo Company Limited (JP) 1989-11-23 EP disclosed
EP-0246739-A2 Macrolide compounds, their preparation and their use SANKYO COMPANY LIMITED (JP) 1987-11-25 EP disclosed