⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5059567 | 0.79 | — | — | |
| SCHEMBL5059570 | 0.78 | — | — | |
| Phosphonoacetohydroxamate SCHEMBL411386 | 0.74 | — | — | |
| SCHEMBL1286786 | 0.74 | — | — | |
| SCHEMBL5059569 | 0.74 | KDM4E (0.33) | — | |
| SCHEMBL7482527 | 0.72 | — | — | |
| SCHEMBL9262545 | 0.71 | FNTA (0.47) | — | |
| SCHEMBL9205480 | 0.70 | MMP2 (0.56) | — | |
| Lithium Ion SCHEMBL28856344 | 0.70 | ENO1 (0.56) | — | |
| SCHEMBL8446275 | 0.69 | ENO1 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5393747-A | Substituted dibenzoxazepine compounds for the treatment of convulsions, ischemia and other diseases responsive to prostaglandin-E2 antagonists | G. D. SEARLE & CO. (US) | 1995-02-28 | — | — | US | claimed |
| EP-0583408-A1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1994-02-23 | — | — | EP | claimed |
| WO-1992019605-A1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G. D. SEARLE & CO. (US) | 1992-11-12 | — | — | WO | claimed |
| US-20080317834-A1 | Compounds and methods for modulating cerebral amyloid angiopathy | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2008-12-25 | — | — | US | disclosed |
| US-20080317834-A1 | Compounds and methods for modulating cerebral amyloid angiopathy | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2008-12-25 | — | — | US | disclosed |
| US-20070078082-A1 | Methods and compositions to treat glycosaminoglycan-associated molecular interactions | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2007-04-05 | — | — | US | disclosed |
| US-20070078082-A1 | Methods and compositions to treat glycosaminoglycan-associated molecular interactions | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2007-04-05 | — | — | US | disclosed |
| US-5393747-A | Substituted dibenzoxazepine compounds for the treatment of convulsions, ischemia and other diseases responsive to prostaglandin-E2 antagonists | G. D. SEARLE & CO. (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0583408-A1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1994-02-23 | — | — | EP | disclosed |
| US-5283240-A | Administering prostaglandin antagonists | G. D. SEARLE & CO. (US) | 1994-02-01 | — | — | US | disclosed |
| US-5182272-A | 8-substituted-dibenz[b,f][1,4]oxazepine-10(11)-carboxylic acid, substituted hydrazides, pharmaceutical compositions, and methods for treating pain | G. D. SEARLE & CO. (US) | 1993-01-26 | — | — | US | disclosed |
| WO-1992019605-A1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G. D. SEARLE & CO. (US) | 1992-11-12 | — | — | WO | disclosed |
| EP-0512399-A1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | G.D. Searle & Co. (US) | 1992-11-11 | — | — | EP | disclosed |
| US-4115558-A | Hydrazone dithiophosphates and phosphonates and use thereof as insecticides | STAUFFER CHEMICAL COMPANY (US) | 1978-09-19 | — | — | US | disclosed |