Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 6/20 | 0.33 |
| ▸ | MAOB | P27338 | 6/20 | 0.33 |
| ▸ | KDM1A | O60341 | 4/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.33 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5407876 | 0.82 | KMT2A (0.38) | MAPTCYP3A4TP53GAAMAOA | |
| SCHEMBL8533570 | 0.80 | CYP1A2 (0.43) | CYP1A2MAPTLMNACYP3A4TP53 | |
| SCHEMBL9403394 | 0.72 | GAA (0.45) | CYP1A2MAPTLMNACYP3A4TP53 | |
| SCHEMBL6045098 | 0.71 | PTGS1 (0.32) | LMNAHTR1A | |
| SCHEMBL876024 | 0.69 | CYP1A2 (0.48) | CYP1A2MAPTLMNACYP3A4TP53 | |
| SCHEMBL10707636 | 0.68 | MAPT (0.52) | CYP1A2MAPTLMNACYP3A4TP53 | |
| SCHEMBL23914271 | 0.67 | CYP19A1 (0.51) | CYP19A1TSHR | |
| SCHEMBL30674005 | 0.67 | CYP19A1 (0.51) | CYP19A1TSHR | |
| SCHEMBL9303316 | 0.65 | ALDH1A1 (0.43) | MAPTLMNAMAPK1GAACYP19A1 | |
| SCHEMBL28438798 | 0.65 | MAPT (0.41) | CYP1A2MAPTLMNACYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5416224-A | Reaction of acetyldihydro-2-(3H)-furanone with aldehyde and alkali metal hydroxide | HENKEL CORPORATION (US) | 1995-05-16 | — | — | US | disclosed |
| EP-0559789-A1 | PROCESS FOR THE PREPARATION OF $g(a)-ALKYL LACTONES | HENKEL CORPORATION (US) | 1993-09-15 | — | — | EP | disclosed |
| US-5231192-A | Reacting an a-acyl lactone, an aldehyde and an alkali metal hydroxide; hydrogenation | HENKEL CORPORATION (US) | 1993-07-27 | — | — | US | disclosed |
| WO-1992010487-A1 | PROCESS FOR CONVERTING α-ACYL-SUBSTITUTED LACTONES TO α-ALKYLIDENE-SUBSTITUTED LACTONES | HENKEL CORPORATION (US) | 1992-06-25 | — | — | WO | disclosed |
| WO-1992009590-A1 | PROCESS FOR THE PREPARATION OF α-ALKYL LACTONES | HENKEL CORPORATION (US) | 1992-06-11 | — | — | WO | disclosed |
| US-4980342-A | Process for the preparation of α-alkyl lactones | HENKEL CORPORATION (US) | 1990-12-25 | — | — | US | disclosed |