SCHEMBL5407876

SCHEMBL5407876

C=C1COC(=O)C1c1ccccc1C1C(=C)COC1=O

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.38
ALDH1A1 P00352 2/20 0.38
MEN1 O00255 2/20 0.38
KDM4E B2RXH2 1/20 0.38
TP53 P04637 1/20 0.38
CYP3A4 P08684 1/20 0.38
MAPT P10636 1/20 0.38
PKM P14618 1/20 0.38
HPGD P15428 1/20 0.38
ALOX15 P16050 1/20 0.38
ALOX12 P18054 1/20 0.38
HSD17B10 Q99714 1/20 0.38
ANPEP P15144 2/20 0.33
MAOA P21397 1/20 0.32
MAOB P27338 1/20 0.32
HTT P42858 1/20 0.31
TERT O14746 1/20 0.30
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9257863 0.82 CYP1A2 (0.41) KMT2ATP53CYP3A4MAPTHSD17B10
SCHEMBL6045098 0.82 PTGS1 (0.32) ALDH1A1
SCHEMBL6308559 0.67 MEN1 (0.43) KMT2AALDH1A1MEN1KDM4ETP53
SCHEMBL14275684 0.67 ANPEP (0.53) ANPEPMAOAMAOB
SCHEMBL8533570 0.65 CYP1A2 (0.43) KMT2ATP53CYP3A4MAPTHSD17B10
SCHEMBL14169739 0.63 MAOA (0.44) ALDH1A1KDM4EMAPTHPGDALOX12
SCHEMBL163049 0.63
SCHEMBL27935622 0.62 ALDH1A1 (0.33) ALDH1A1
SCHEMBL14616986 0.62 MEN1 (0.55) KMT2AALDH1A1MEN1KDM4ETP53
SCHEMBL31151845 0.62 MEN1 (0.55) KMT2AALDH1A1MEN1KDM4ETP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7166274-B2 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds L'OREAL (FR) 2007-01-23 US claimed
US-20040047820-A1 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds SOCIETE L'OREAL S.A. (FR) 2004-03-11 US claimed
US-6627180-B2 Particles having protection factor UV-APPD and an amino substituted 2-hydroxybenzophenone SOCIETE L'OREAL S.A. (FR) 2003-09-30 US claimed
US-20030152532-A1 SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS SOCIETE L'OREAL S.A. (FR) 2003-08-14 US claimed
US-20150190320-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES L'OREAL (FR) 2015-07-09 US disclosed
US-20150157539-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES L'OREAL (FR) 2015-06-11 US disclosed
WO-2014010100-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES L'OREAL (FR) 2014-01-16 WO disclosed
WO-2014010098-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES L'OREAL (FR) 2014-01-16 WO disclosed
WO-2014010099-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARING THE SAME L'OREAL (FR) 2014-01-16 WO disclosed
US-7166274-B2 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds L'OREAL (FR) 2007-01-23 US disclosed
US-20040047820-A1 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds SOCIETE L'OREAL S.A. (FR) 2004-03-11 US disclosed
US-6627180-B2 Particles having protection factor UV-APPD and an amino substituted 2-hydroxybenzophenone SOCIETE L'OREAL S.A. (FR) 2003-09-30 US disclosed
US-20030152532-A1 SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS SOCIETE L'OREAL S.A. (FR) 2003-08-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040047820-A1 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds SUCLG1, CUTA, DLD KMT2A 3376/4885ALDH1A1 246/4885MEN1 4027/4885
US-20150157539-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES MITF, RAB5IF, TYR KMT2A 3148/4885ALDH1A1 281/4885MEN1 341/4885
US-20030152532-A1 SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS HADHB, SDHA, ERCC4 KMT2A 3626/4885ALDH1A1 193/4885MEN1 3716/4885
US-20150190320-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES XPA, ERCC1, ERCC4 KMT2A 3290/4885ALDH1A1 331/4885MEN1 866/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.