Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9123705 | 0.84 | MAOA (0.50) | MAOAMAOBPLAUANPEP | |
| SCHEMBL29539739 | 0.74 | IDO1 (0.41) | IDO1PLAUANPEPDRD3 | |
| SCHEMBL385635 | 0.74 | IDO1 (0.41) | IDO1PLAUANPEP | |
| SCHEMBL1415621 | 0.74 | IDO1 (0.41) | IDO1PLAUANPEPDRD3 | |
| SCHEMBL2725956 | 0.66 | CYP1A2 (0.51) | MAOAMAOBPLAUANPEP | |
| SCHEMBL691835 | 0.66 | PLAU (0.50) | MAOAMAOBPLAUANPEP | |
| SCHEMBL23978878 | 0.64 | IDO1 (0.47) | IDO1MAOAMAOBDRD2 | |
| SCHEMBL7332248 | 0.63 | FAAH (0.47) | IDO1ANPEP | |
| SCHEMBL5870921 | 0.63 | IDO1 (0.46) | IDO1PLAUANPEPDRD3 | |
| SCHEMBL20095994 | 0.63 | ANPEP (0.56) | IDO1PLAUANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0490772-B1 | 1,4-Disubstituted piperazines, their process of preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-07-26 | — | — | EP | disclosed |