Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 6/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9257881 | 1.00 | GRM2 (0.47) | GRM2CLK1DYRK1ADYRK1BCYP1A2 | |
| SCHEMBL7996076 | 0.85 | DYRK1A (0.62) | GRM2CLK1DYRK1ADYRK1BCYP1A2 | |
| SCHEMBL983907 | 0.85 | CYP1A2 (0.49) | CLK1DYRK1ADYRK1BCYP1A2ALDH1A1 | |
| SCHEMBL9252871 | 0.83 | USP18 (0.48) | CLK1DYRK1ADYRK1BALDH1A1MEN1 | |
| SCHEMBL9252868 | 0.83 | USP18 (0.48) | CLK1DYRK1ADYRK1BALDH1A1MEN1 | |
| SCHEMBL7992606 | 0.80 | MAPT (0.50) | CLK1DYRK1ADYRK1BCYP1A2ALDH1A1 | |
| SCHEMBL9253106 | 0.77 | GRM2 (0.39) | GRM2CYP1A2PPARGSIRT2 | |
| SCHEMBL9261410 | 0.76 | PRKCA (0.43) | GRM2CYP1A2PPARGSIRT2 | |
| SCHEMBL9261402 | 0.76 | PRKCA (0.43) | GRM2CYP1A2PPARGSIRT2 | |
| SCHEMBL981312 | 0.73 | DYRK1A (0.69) | CLK1DYRK1ADYRK1BCYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5416224-A | Reaction of acetyldihydro-2-(3H)-furanone with aldehyde and alkali metal hydroxide | HENKEL CORPORATION (US) | 1995-05-16 | — | — | US | disclosed |
| EP-0559789-A1 | PROCESS FOR THE PREPARATION OF $g(a)-ALKYL LACTONES | HENKEL CORPORATION (US) | 1993-09-15 | — | — | EP | disclosed |
| US-5231192-A | Reacting an a-acyl lactone, an aldehyde and an alkali metal hydroxide; hydrogenation | HENKEL CORPORATION (US) | 1993-07-27 | — | — | US | disclosed |
| WO-1992010487-A1 | PROCESS FOR CONVERTING α-ACYL-SUBSTITUTED LACTONES TO α-ALKYLIDENE-SUBSTITUTED LACTONES | HENKEL CORPORATION (US) | 1992-06-25 | — | — | WO | disclosed |
| WO-1992009590-A1 | PROCESS FOR THE PREPARATION OF α-ALKYL LACTONES | HENKEL CORPORATION (US) | 1992-06-11 | — | — | WO | disclosed |
| US-4980342-A | Process for the preparation of α-alkyl lactones | HENKEL CORPORATION (US) | 1990-12-25 | — | — | US | disclosed |