SCHEMBL9257943

SCHEMBL9257943

C=CCN1c2ccccc2Sc2cc(C=O)ccc21

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.44
MEN1 O00255 4/20 0.44
POLB P06746 2/20 0.44
LMNA P02545 1/20 0.39
NOX1 Q9Y5S8 2/20 0.39
HDAC6 Q9UBN7 1/20 0.39
MMP13 P45452 1/20 0.38
KDM1A O60341 3/20 0.38
ALDH1A1 P00352 1/20 0.38
PTGS1 P23219 2/20 0.37
PTGS2 P35354 2/20 0.37
MAPT P10636 2/20 0.37
PIM1 P11309 1/20 0.37
APP P05067 1/20 0.36
ADRA2A P08913 1/20 0.36
ADRA2B P18089 1/20 0.36
ADRA2C P18825 1/20 0.36
CHRM3 P20309 1/20 0.36
SLC6A2 P23975 1/20 0.36
HTR2C P28335 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29376932 0.83 KMT2A (0.52) KMT2AMEN1POLBLMNAKDM1A
SCHEMBL39172 0.83 KMT2A (0.52) KMT2AMEN1POLBLMNAKDM1A
SCHEMBL4632567 0.83 ALDH1A1 (0.48) KMT2AMEN1POLBLMNANOX1
SCHEMBL31481617 0.83 ALDH1A1 (0.48) KMT2AMEN1POLBLMNANOX1
Iodide SCHEMBL11442732 0.82 KMT2A (0.51) KMT2AMEN1POLBLMNAMMP13
SCHEMBL5115700 0.82 PIM1 (0.55) KMT2AMEN1LMNAKDM1AALDH1A1
SCHEMBL5112085 0.82 PIM1 (0.55) KMT2AMEN1LMNAKDM1AALDH1A1
SCHEMBL29376040 0.81 PDF (0.48) KMT2AMEN1POLBLMNANOX1
SCHEMBL25842328 0.81 PDF (0.48) KMT2AMEN1POLBLMNANOX1
SCHEMBL15603425 0.81 ALDH1A1 (0.41) KMT2AMEN1POLBALDH1A1PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0274589-B1 Lubricating oil containing dispersant viscosity index improver TEXACO DEVELOPMENT CORP (US) 1995-05-10 EP disclosed
US-4952637-A CONTAINING N-VINYL PYRROLIDONE AND PHENOTHIAZINE TEXACO INC. (US) 1990-08-28 US disclosed
US-4886611-A LUBRICANTS; GRAFTED WITH N-VINYL PYRROLIDONE AND PHENOTHIAZINE TEXACO INC. (US) 1989-12-12 US disclosed
US-4877415-A HYDROCARBON FUEL CONTAINING AS DISPERSANT A GRAF POLYMER OF OLEFINS, AMINE, AND A PHENOTHIAZINE TEXACO INC. (US) 1989-10-31 US disclosed
US-4820776-A Hydrocarbon compositions containing polyolefin graft polymers having amine and phenothiazine grafted moieties TEXACO INC. (US) 1989-04-11 US disclosed
US-4816172-A VISCOSITY IMPROVERS, LUBRICANTS TEXACO INC. (US) 1989-03-28 US disclosed
US-4795577-A MODIFIED ISOCYANATOALKYL ACRYLATE COPOLYMERS TEXACO INC. (US) 1989-01-03 US disclosed
US-4790948-A MODIFYING ADDITION COPOLYMER OF UNSATURATED EPOXIDES WITH POLYAMINE AND SULFUR-NITROGEN HETEROCYCLIC COMPOUND TEXACO INC. (US) 1988-12-13 US disclosed
US-4767553-A POLYMER OF UNSATURATED ANHYDRIDE AND A (METH)ACRYLATE FUNCTIONALIZED WITH PHENOTHIAZINE AND A HETEROCYCLIC PRIMARY OR SECONDARY AMINE TEXACO INC. (US) 1988-08-30 US disclosed
EP-0274589-A2 Lubricating oil containing dispersant viscosity index improver TEXACO DEVELOPMENT CORPORATION (US) 1988-07-20 EP disclosed