Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | AGXT | P21549 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | ACLY | P53396 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.30 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.30 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6132650 | 0.77 | KDM5A (0.36) | ALDH1A1 | |
| SCHEMBL30516569 | 0.77 | KDM5A (0.36) | ALDH1A1 | |
| SCHEMBL5672566 | 0.76 | PYCR1 (0.35) | IDO1ALDH1A1MAPK1 | |
| SCHEMBL9472699 | 0.76 | IDO1 (0.37) | IDO1AGXT | |
| SCHEMBL7488069 | 0.75 | CYP17A1 (0.46) | IDO1AGXTSLC16A3 | |
| SCHEMBL6298659 | 0.75 | PYCR1 (0.35) | IDO1ALDH1A1MAPK1 | |
| SCHEMBL21543547 | 0.74 | IDO1 (0.38) | IDO1ALDH1A1SLC16A3SLC16A1MCTS1 | |
| SCHEMBL17159412 | 0.74 | LMNA (0.37) | ALDH1A1 | |
| SCHEMBL4821504 | 0.74 | SMYD2 (0.33) | — | |
| SCHEMBL9080536 | 0.73 | SMYD2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659179-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1995-08-09 | — | — | EP | disclosed |
| EP-0659179-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-06-28 | — | — | EP | disclosed |