Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 13/20 | 0.52 |
| ▸ | NPC1 | O15118 | 12/20 | 0.52 |
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL924944 | 0.89 | RAB9A (0.55) | RAB9ANPC1MAPTATMSMN1; SMN2 | |
| SCHEMBL925616 | 0.88 | RAB9A (0.53) | RAB9ANPC1MAPTATMSMN1; SMN2 | |
| SCHEMBL925883 | 0.84 | HTR2C (0.43) | RAB9ANPC1MAPTSMN1; SMN2TP53 | |
| SCHEMBL924865 | 0.84 | RAB9A (0.55) | RAB9ANPC1MAPTATMSMN1; SMN2 | |
| SCHEMBL3570499 | 0.84 | RAB9A (0.51) | RAB9ANPC1MAPTATMSMN1; SMN2 | |
| SCHEMBL924866 | 0.81 | NAMPT (0.55) | RAB9ANPC1MAPTATMSMN1; SMN2 | |
| SCHEMBL15361982 | 0.76 | RAB9A (0.52) | RAB9ANPC1MAPTATMSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3573666 | 0.76 | RAB9A (0.52) | RAB9ANPC1MAPTATMSMN1; SMN2 | |
| SCHEMBL3570067 | 0.76 | RAB9A (0.49) | RAB9ANPC1MAPTATMSMN1; SMN2 | |
| SCHEMBL3153127 | 0.74 | RAB9A (0.60) | RAB9ANPC1MAPTATMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125787-B1 | DERIVATIVES OF N-(HETEROARYL)-1-HETEROARYL-1H-INDOL-2-CARBOXAMIDS, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2017-03-01 | — | — | EP | disclosed |
| US-7868024-B2 | Derivatives of N-(heteroaryl)-1-heteroaryl-1H-indole-2-carboxamides, preparation thereof and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2011-01-11 | — | — | US | disclosed |
| US-20090306143-A1 | Derivatives of N-(heteroaryl)-1-heteroaryl-1H-indole-2-carboxamides, preparation thereof and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306143-A1 | Derivatives of N-(heteroaryl)-1-heteroaryl-1H-indole-2-carboxamides, preparation thereof and therapeutic use thereof | IDO1, IDO2, KYNU | RAB9A 3168/4885NPC1 1252/4885MAPT 3659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.