Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.43 |
| ▸ | CA9 | Q16790 | 4/20 | 0.43 |
| ▸ | GSK3A | P49840 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GRM6 | O15303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9260491 | 0.86 | CA12 (0.60) | CA12CA9 | |
| SCHEMBL9259394 | 0.86 | CA12 (0.46) | CA12CA9ALDH1A1MAPTPTGS2 | |
| SCHEMBL2389058 | 0.84 | CA12 (0.64) | CA12CA9MEN1CYP2C19KMT2A | |
| SCHEMBL5166002 | 0.83 | CA12 (0.43) | CA12CA9GRIN2DGRIN3BGRIN1 | |
| SCHEMBL5167851 | 0.83 | CA9 (0.40) | CA12CA9GRIN2DGRIN3BGRIN1 | |
| SCHEMBL5165208 | 0.81 | NQO2 (0.42) | CA12CA9KDM4EALDH1A1MAPT | |
| SCHEMBL5167310 | 0.81 | ALDH1A1 (0.40) | CA12CA9GRIN2DGRIN3BGRIN1 | |
| SCHEMBL5455598 | 0.80 | GRIK1 (0.51) | CA12CA9GRIK1GRIA1GRIA2 | |
| SCHEMBL5179666 | 0.80 | CA12 (0.38) | CA12CA9GRIN2DGRIN3BGRIN1 | |
| SCHEMBL5179781 | 0.79 | MAPT (0.46) | ALDH1A1MAPTCYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995019346-A1 | QUINAZOLINE-2,4-DIONES | SANDOZ LTD. (CH) | 1995-07-20 | — | — | WO | claimed |
| WO-1995019346-A1 | QUINAZOLINE-2,4-DIONES | SANDOZ LTD. (CH) | 1995-07-20 | — | — | WO | disclosed |