Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 10/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 9/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450038 | 0.96 | ALOX15 (0.53) | ALOX15TSHRCASP1RAB9AMEN1 | |
| SCHEMBL29183439 | 0.88 | PSMB8 (0.46) | ALOX15TSHRCASP1RAB9AMEN1 | |
| SCHEMBL29183388 | 0.82 | NPC1 (0.48) | ALOX15TSHRCASP1RAB9AMEN1 | |
| SCHEMBL28128556 | 0.82 | NPC1 (0.50) | ALOX15TSHRCASP1RAB9AMEN1 | |
| SCHEMBL15874209 | 0.82 | KDM4E (0.49) | ALOX15TSHRCASP1RAB9ANPC1 | |
| SCHEMBL29183431 | 0.82 | ALDH1A1 (0.51) | ALOX15TSHRCASP1RAB9ANPC1 | |
| SCHEMBL15062653 | 0.80 | NPC1 (0.47) | ALOX15TSHRCASP1RAB9AMEN1 | |
| SCHEMBL27790043 | 0.79 | CYP3A4 (0.59) | RAB9AMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL29183414 | 0.78 | KDM4E (0.55) | RAB9AKMT2ANPC1SMN1; SMN2HPGD | |
| SCHEMBL21219959 | 0.78 | TSHR (0.53) | ALOX15TSHRCASP1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5464849-A | N-hydroxyurea derivatives as antiallergy and antiinflammatory agents | PFIZER INC. (US) | 1995-11-07 | — | — | US | disclosed |
| EP-0566593-A1 | N-HYDROXYUREA DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1993-10-27 | — | — | EP | disclosed |
| WO-1992012141-A1 | N-HYDROXYUREA DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-07-23 | — | — | WO | disclosed |