Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 7/20 | 0.64 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.64 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.64 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.53 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259917 | 0.90 | GABRG2 (0.77) | GABRG2GABRB3GABRA5GABRA1GABRB2 | |
| SCHEMBL9263501 | 0.90 | GABRG2 (0.65) | GABRG2GABRB3GABRA5GABRA1GABRB2 | |
| SCHEMBL9262828 | 0.88 | GABRA1 (0.61) | GABRG2GABRB3GABRA5GABRA1GABRB2 | |
| SCHEMBL9266435 | 0.83 | GABRG2 (0.59) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9265482 | 0.80 | GABRG2 (0.60) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9260177 | 0.80 | GABRA1 (0.52) | GABRG2GABRB3GABRA5GABRA1GABRB2 | |
| SCHEMBL9264342 | 0.79 | GABRG2 (0.58) | GABRG2GABRB3GABRA5GABRA1GABRB2 | |
| SCHEMBL9259578 | 0.78 | GABRG2 (0.70) | GABRG2GABRB3GABRA5GABRA1GABRB2 | |
| SCHEMBL9259595 | 0.78 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRB2 | |
| SCHEMBL9268100 | 0.77 | GABRG2 (0.67) | GABRG2GABRB3GABRA5GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5387585-A | Treating epilepsy, anxiety, sleep disorders, schizophrnia, senile dementia | HOFFMANN-LA ROCHE INC. (US) | 1995-02-07 | — | — | US | disclosed |
| EP-0519307-A2 | Tetracyclic Imidazodiazepines | F. HOFFMANN-LA ROCHE AG (CH) | 1992-12-23 | — | — | EP | disclosed |