Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
| ▸ | CASP2 | P42575 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.46 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NAAA | Q02083 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9789508 | 0.91 | EPHX2 (0.56) | ADRA1APRMT1EPHX2PLA2G10PLA2G2A | |
| SCHEMBL599560 | 0.91 | EPHX2 (0.56) | ADRA1APRMT1EPHX2PLA2G10PLA2G2A | |
| SCHEMBL8576664 | 0.91 | EPHX2 (0.56) | ADRA1APRMT1EPHX2PLA2G10PLA2G2A | |
| SCHEMBL16689691 | 0.87 | ALDH1A1 (0.53) | ALDH1A1CASP2KDM4EKDM4CKDM4A | |
| SCHEMBL22851659 | 0.87 | ALDH1A1 (0.53) | ALDH1A1CASP2KDM4EKDM4CKDM4A | |
| SCHEMBL18768756 | 0.87 | ALDH1A1 (0.53) | ALDH1A1CASP2KDM4EKDM4CKDM4A | |
| SCHEMBL21675625 | 0.86 | KDM4C (0.50) | ADRA1APRMT1EPHX2ALDH1A1PLA2G10 | |
| SCHEMBL10174293 | 0.86 | LMNA (0.51) | ADRA1APRMT1EPHX2ALDH1A1PLA2G10 | |
| SCHEMBL19239788 | 0.85 | ALDH1A1 (0.52) | EPHX2ALDH1A1CASP2KDM4CNAMPT | |
| SCHEMBL16399076 | 0.85 | ALDH1A1 (0.55) | ALDH1A1PLA2G10KDM4CKDM4APHF8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5391564-A | E.g., rhizoxin-13-yl 3-methylthiopropionate; anticarcinogenic agents | SANKYO COMPANY, LIMITED (JP) | 1995-02-21 | — | — | US | disclosed |
| US-5352689-A | Rhizoxin derivatives and their use as anti-tumor agents | SANKYO COMPANY, LIMITED (JP) | 1994-10-04 | — | — | US | disclosed |
| EP-0350315-B1 | RHIZOXIN DERIVATES AND THEIR USE AS ANTI-TUMOR AGENTS | SANKYO COMPANY LIMITED (JP) | 1993-06-16 | — | — | EP | disclosed |
| EP-0350315-A1 | Rhizoxin derivates and their use as anti-tumor agents | SANKYO COMPANY LIMITED (JP) | 1990-01-10 | — | — | EP | disclosed |