Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.54 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259700 | 0.92 | SMN1; SMN2 (0.65) | ALDH1A1ALOX12SMN1; SMN2MITFACHE | |
| SCHEMBL542239 | 0.85 | TDP1 (0.74) | ALDH1A1SMN1; SMN2TDP1ACHELMNA | |
| Hydrochloric Acid SCHEMBL7576777 | 0.83 | TDP1 (0.72) | ALDH1A1SMN1; SMN2TDP1ACHELMNA | |
| SCHEMBL14946919 | 0.83 | ALDH1A1 (0.69) | ALDH1A1ALOX12SMN1; SMN2MITFLMNA | |
| SCHEMBL15328470 | 0.83 | ALDH1A1 (0.78) | ALDH1A1ALOX12SMN1; SMN2MITFLMNA | |
| SCHEMBL12069946 | 0.80 | SMN1; SMN2 (0.68) | ALDH1A1ALOX12SMN1; SMN2MITFACHE | |
| SCHEMBL15328268 | 0.80 | SMN1; SMN2 (0.77) | ALDH1A1ALOX12SMN1; SMN2MITFACHE | |
| SCHEMBL2348030 | 0.80 | ALDH1A1 (0.68) | ALDH1A1ALOX12SMN1; SMN2MITFLMNA | |
| Ammonia Solution, Strong SCHEMBL29260484 | 0.80 | ALDH1A1 (0.68) | ALDH1A1ALOX12SMN1; SMN2MITFLMNA | |
| SCHEMBL11581830 | 0.79 | SMN1; SMN2 (0.72) | ALDH1A1ALOX12SMN1; SMN2MITFACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378706-A | Memory disorders, senile dememtia | SANOFI (FR) | 1995-01-03 | — | — | US | disclosed |
| US-5232921-A | Thiazole derivatives active on the cholinergic system, process for obtention and pharmaceutical compositions | SANOFI (FR) | 1993-08-03 | — | — | US | disclosed |