Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.58 |
| ▸ | ACHE | P22303 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259868 | 0.92 | ALDH1A1 (0.61) | SMN1; SMN2ALDH1A1ALOX12ACHEMEN1 | |
| SCHEMBL12069946 | 0.86 | SMN1; SMN2 (0.68) | SMN1; SMN2ALDH1A1ALOX12ACHEMEN1 | |
| SCHEMBL9628332 | 0.86 | NAAA (0.64) | ALDH1A1ACHEMEN1KMT2ACYP2D6 | |
| SCHEMBL15328268 | 0.84 | SMN1; SMN2 (0.77) | SMN1; SMN2ALDH1A1ALOX12ACHEMEN1 | |
| SCHEMBL11581830 | 0.83 | SMN1; SMN2 (0.72) | SMN1; SMN2ALDH1A1ALOX12ACHEMEN1 | |
| SCHEMBL16587380 | 0.82 | NAAA (0.72) | SMN1; SMN2ALDH1A1ALOX12ACHEMEN1 | |
| SCHEMBL16587395 | 0.82 | NAAA (0.72) | SMN1; SMN2ALDH1A1ALOX12ACHEMEN1 | |
| SCHEMBL16587391 | 0.82 | NAAA (0.72) | SMN1; SMN2ALDH1A1ALOX12ACHEMEN1 | |
| SCHEMBL21894756 | 0.82 | NAAA (0.72) | SMN1; SMN2ALDH1A1ALOX12ACHEMEN1 | |
| SCHEMBL14946919 | 0.81 | ALDH1A1 (0.69) | SMN1; SMN2ALDH1A1ALOX12MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378706-A | Memory disorders, senile dememtia | SANOFI (FR) | 1995-01-03 | — | — | US | disclosed |
| US-5232921-A | Thiazole derivatives active on the cholinergic system, process for obtention and pharmaceutical compositions | SANOFI (FR) | 1993-08-03 | — | — | US | disclosed |