Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 14/20 | 0.58 |
| ▸ | MDH2 | P40926 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 5/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9261167 | 0.90 | ACHE (0.56) | ACHEMDH2PDE5A | |
| SCHEMBL5069646 | 0.84 | ACHE (0.56) | ACHEPDE5A | |
| SCHEMBL9255402 | 0.82 | ACHE (0.58) | ACHEPDE5A | |
| SCHEMBL9844705 | 0.81 | ACHE (0.57) | ACHEPDE5A | |
| SCHEMBL7274549 | 0.74 | ACHE (0.52) | ACHE | |
| SCHEMBL9046728 | 0.73 | ACHE (1.00) | ACHE | |
| SCHEMBL7274924 | 0.72 | ACHE (0.57) | ACHE | |
| SCHEMBL7281401 | 0.72 | ACHE (0.52) | ACHE | |
| SCHEMBL7272662 | 0.71 | ACHE (0.49) | ACHE | |
| SCHEMBL9046220 | 0.71 | ACHE (1.00) | ACHEOPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | claimed |
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | disclosed |