Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | GLA | P06280 | 3/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1859838 | 0.76 | CDK4 (0.39) | CDK4CCND1KDM4EALDH1A1HPGD | |
| SCHEMBL4501936 | 0.75 | CDK4 (0.43) | CDK4CCND1KDM4EALDH1A1HPGD | |
| SCHEMBL29089487 | 0.70 | CDK4 (0.42) | CDK4CCND1KDM4EALDH1A1HPGD | |
| SCHEMBL1202590 | 0.69 | CDK4 (0.41) | CDK4CCND1KDM4EALDH1A1HPGD | |
| SCHEMBL420380 | 0.69 | CDK4 (0.54) | CDK4CCND1KDM4EALDH1A1HPGD | |
| SCHEMBL3888976 | 0.68 | CYP3A4 (0.37) | KDM4EALDH1A1MAPTKMT2ARAD52 | |
| SCHEMBL8132839 | 0.67 | ESR1 (0.40) | KDM4EALDH1A1HPGDGLAMAOA | |
| SCHEMBL60730 | 0.66 | LMNA (0.55) | CDK4CCND1KDM4EALDH1A1HPGD | |
| SCHEMBL5476684 | 0.65 | KDM4E (0.52) | CDK4CCND1KDM4EALDH1A1HPGD | |
| SCHEMBL10944923 | 0.65 | ALDH1A1 (0.61) | CDK4CCND1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0037784-B1 | INDOLOBENZOXAZINE DERIVATIVES, THEIR SALTS, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1984-08-01 | — | — | EP | claimed |
| US-4318910-A | Indolobenzoxazines | ROUSSEL UCLAF (FR) | 1982-03-09 | — | — | US | claimed |
| JP-6287193-A | — | — | None | — | — | JP | disclosed |
| US-5466689-A | Analgesics | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-11-14 | — | — | US | disclosed |
| JP-H06287193-A | CONDENSED MORPHOLINE DERIVATIVE | TAKEDA CHEM IND LTD | 1994-10-11 | — | — | JP | disclosed |
| EP-0610793-A1 | Tetracyclic morpholine derivatives and their use or analgesics | Takeda Chemical Industries, Ltd. (JP) | 1994-08-17 | — | — | EP | disclosed |
| US-4503053-A | HYPOTENSIVE, DOPAMINERGIC AGONIST, ANTIANOXIC, PROLACTIN SECRETION INHIBITION | ROUSSEL UCLAF (FR) | 1985-03-05 | — | — | US | disclosed |
| US-4493836-A | HYPOTENSIVE, ANTISEROTONINE AGENTS, DOPAMINE ANTAGONIST | Uclaf, Roussel (FR) | 1985-01-15 | — | — | US | disclosed |
| EP-0033767-B1 | INDOLOBENZOXAZINES, PROCESSES FOR PREPARING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | MERCK & CO. INC. (US) | 1984-06-27 | — | — | EP | disclosed |
| EP-0033767-B1 | INDOLOBENZOXAZINES, PROCESSES FOR PREPARING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | MERCK & CO. INC. (US) | 1984-06-27 | — | — | EP | disclosed |
| US-4420480-A | PARKINSONISM, DEPRESSION, HYPOTENSIVES | MERCK & CO., INC. (US) | 1983-12-13 | — | — | US | disclosed |
| US-4318910-A | Indolobenzoxazines | ROUSSEL UCLAF (FR) | 1982-03-09 | — | — | US | disclosed |
| US-4318910-A | Indolobenzoxazines | ROUSSEL UCLAF (FR) | 1982-03-09 | — | — | US | disclosed |
| EP-0037784-A1 | Indolobenzoxazine derivatives, their salts, process for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1981-10-14 | — | — | EP | disclosed |
| EP-0033767-A1 | Indolobenzoxazines, processes for preparing and pharmaceutical compositions containing the same | MERCK & CO. INC. (US) | 1981-08-19 | — | — | EP | disclosed |
| EP-0033767-A1 | Indolobenzoxazines, processes for preparing and pharmaceutical compositions containing the same | MERCK & CO. INC. (US) | 1981-08-19 | — | — | EP | disclosed |
| EP-0033767-A1 | Indolobenzoxazines, processes for preparing and pharmaceutical compositions containing the same | MERCK & CO. INC. (US) | 1981-08-19 | — | — | EP | disclosed |
| US-4238486-A | TREATING HYPERTENSION AND PARKINSON*S DISEASE | MERCK & CO., INC. (US) | 1980-12-09 | — | — | US | disclosed |
| US-4238486-A | TREATING HYPERTENSION AND PARKINSON*S DISEASE | MERCK & CO., INC. (US) | 1980-12-09 | — | — | US | disclosed |
| US-4238486-A | TREATING HYPERTENSION AND PARKINSON*S DISEASE | MERCK & CO., INC. (US) | 1980-12-09 | — | — | US | disclosed |