SCHEMBL9260574

SCHEMBL9260574

CCOC(=O)c1cn(C2CSC2)c2cc(F)c(F)cc2c1=O

nearest known ligand 0.63

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.57
KDM4E B2RXH2 5/20 0.53
ALDH1A1 P00352 5/20 0.53
HPGD P15428 5/20 0.53
HSD17B10 Q99714 4/20 0.53
ADRB2 P07550 1/20 0.47
LMNA P02545 3/20 0.45
MAPT P10636 2/20 0.45
STAT3 P40763 2/20 0.43
MEN1 O00255 2/20 0.41
HTT P42858 1/20 0.41
THRB P10828 1/20 0.41
POLB P06746 1/20 0.40
CYP1A2 P05177 1/20 0.40
TOP2A P11388 1/20 0.40
CYP2C9 P11712 1/20 0.40
TOP2B Q02880 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4306583 0.90 KMT2A (0.60) KMT2AKDM4EALDH1A1HPGDHSD17B10
SCHEMBL29576844 0.90 KMT2A (0.60) KMT2AKDM4EALDH1A1HPGDHSD17B10
SCHEMBL9270695 0.87 KMT2A (0.57) KMT2AKDM4EALDH1A1HPGDHSD17B10
SCHEMBL9264329 0.86 ADRB2 (0.58) KMT2AKDM4EALDH1A1HPGDHSD17B10
SCHEMBL1243804 0.84 KMT2A (0.54) KMT2AKDM4EALDH1A1HPGDHSD17B10
SCHEMBL7889765 0.83 KMT2A (0.58) KMT2AKDM4EALDH1A1HPGDHSD17B10
SCHEMBL10364617 0.83 KMT2A (0.58) KMT2AKDM4EALDH1A1HPGDHSD17B10
SCHEMBL1243388 0.83 KMT2A (0.53) KMT2AKDM4EALDH1A1HPGDHSD17B10
SCHEMBL10577000 0.82 KMT2A (0.54) KMT2AKDM4EALDH1A1HPGDHSD17B10
SCHEMBL9264216 0.82 KDM4E (0.56) KDM4EALDH1A1HPGDHSD17B10LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5407932-A Bactericides WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1995-04-18 US disclosed
EP-0393400-B1 Novel quinolone derivatives, preparation processes thereof, and antibacterial agents containing the same WAKUNAGA SEIYAKU KK (JP) 1994-12-21 EP disclosed
US-5245037-A Synthetic bactericides WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1993-09-14 US disclosed
EP-0393400-A1 Novel quinolone derivatives, preparation processes thereof, and antibacterial agents containing the same WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1990-10-24 EP disclosed