Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 9/20 | 0.42 |
| ▸ | TACR2 | P21452 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 5/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9282529 | 0.86 | HRH1 (0.40) | HRH1TACR2TACR1RENCNR2 | |
| SCHEMBL9258963 | 0.85 | HRH1 (0.42) | HRH1TACR2TACR1HSD17B10ALDH1A1 | |
| SCHEMBL9260568 | 0.85 | HRH1 (0.48) | HRH1TACR2TACR1 | |
| SCHEMBL9268866 | 0.85 | HRH1 (0.43) | HRH1TACR2TACR1F10HSD17B10 | |
| SCHEMBL9260991 | 0.82 | HRH1 (0.51) | HRH1TACR2TACR1RENLMNA | |
| SCHEMBL9259877 | 0.81 | HRH1 (0.49) | HRH1TACR2TACR1CNR2TP53 | |
| SCHEMBL9258370 | 0.81 | HRH1 (0.62) | HRH1TACR2TACR1TP53ALDH1A1 | |
| SCHEMBL9260703 | 0.79 | HRH1 (0.42) | HRH1TACR2TACR1RENCNR2 | |
| SCHEMBL9268629 | 0.78 | HRH1 (0.45) | HRH1TACR2TACR1CNR2TP53 | |
| SCHEMBL9268701 | 0.78 | HRH1 (0.53) | HRH1TACR2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5380731-A | Antiallergic compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0561973-A1 | ANTIALLERGIC COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-09-29 | — | — | EP | disclosed |
| WO-1992010491-A1 | ANTIALLERGIC COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-06-25 | — | — | WO | disclosed |