Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.56 |
| ▸ | CA4 | P22748 | 2/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.35 |
| ▸ | GRIA3 | P42263 | 4/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2726839 | 1.00 | CA2 (0.56) | CA2CA4CA12CA1CA6 | |
| SCHEMBL7846811 | 0.97 | CA2 (0.53) | CA2CA4CA12CA1CA6 | |
| SCHEMBL7843136 | 0.93 | CA2 (0.47) | CA2CA4CA12CA1CA6 | |
| SCHEMBL12603507 | 0.86 | CA2 (0.56) | CA2CA4CA12CA1CA6 | |
| SCHEMBL2631337 | 0.86 | CA2 (0.53) | CA2CA4CA12CA1CA6 | |
| SCHEMBL3586580 | 0.84 | CA2 (0.79) | CA2CA4CA12CA1CA6 | |
| SCHEMBL2631258 | 0.84 | CA2 (0.79) | CA2CA4CA12CA1CA6 | |
| SCHEMBL3576264 | 0.84 | CA2 (0.79) | CA2CA4CA12CA1CA6 | |
| SCHEMBL12603511 | 0.82 | CA2 (0.50) | CA2CA4CA12CA1CA6 | |
| SCHEMBL8950329 | 0.82 | CA2 (0.36) | CA2CA4CA12CA1CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8344136-B2 | Process for the preparation of brinzolamide | PHF S.A. (CH) | 2013-01-01 | — | — | US | disclosed |
| US-8344136-B2 | Process for the preparation of brinzolamide | PHF S.A. (CH) | 2013-01-01 | — | — | US | disclosed |
| US-20110118461-A1 | PROCESS FOR THE PREPARATION OF BRINZOLAMIDE | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2011-05-19 | — | — | US | disclosed |
| US-20110118461-A1 | PROCESS FOR THE PREPARATION OF BRINZOLAMIDE | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2011-05-19 | — | — | US | disclosed |
| WO-2010103550-A2 | PROCESS FOR THE PREPARATION OF INTERMEDIATES | INDOCO REMEDIES LIMITED (IN) | 2010-09-16 | — | — | WO | disclosed |
| WO-2010004457-A2 | PROCESS FOR THE PREPARATION OF BRINZOLAMIDE | PHF SA (CH) | 2010-01-14 | — | — | WO | disclosed |
| US-5470973-A | Synthesis of sulfonamide intermediates | ALCON LABORATORIES, INC. (US) | 1995-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118461-A1 | PROCESS FOR THE PREPARATION OF BRINZOLAMIDE | CYP3A4, CYP4B1, SULT1E1 | CA2 1003/4885CA4 327/4885CA12 3313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.