Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.55 |
| ▸ | FPR2 | P25090 | 2/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.48 |
| ▸ | TPH1 | P17752 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9257412 | 0.99 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DFPR2 | |
| SCHEMBL9266611 | 0.99 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DFPR2 | |
| SCHEMBL9269661 | 0.85 | PDE4D (0.46) | PDE4APDE4BPDE4CPDE4DFPR2 | |
| SCHEMBL9183609 | 0.85 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DFPR2 | |
| SCHEMBL1752782 | 0.83 | ALDH1A1 (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5823060 | 0.80 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DFPR2 | |
| SCHEMBL7416259 | 0.80 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DFPR2 | |
| SCHEMBL9265518 | 0.79 | TRPC6 (0.50) | PDE4APDE4BPDE4CPDE4DFPR2 | |
| SCHEMBL9185677 | 0.79 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL7450822 | 0.78 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5449676-A | Bronchodilator agents | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1995-09-12 | — | — | US | disclosed |
| EP-0581805-A1 | NOVEL PYRIDAZINES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1994-02-09 | — | — | EP | disclosed |
| WO-1992019602-A1 | NOVEL PYRIDAZINES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1992-11-12 | — | — | WO | disclosed |
| EP-0510562-A1 | Pyridazines | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1992-10-28 | — | — | EP | disclosed |