Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2398565 | 0.89 | POLB (0.48) | POLBALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL10774498 | 0.87 | POLB (0.66) | POLBALDH1A1SMN1; SMN2SRD5A2MAPT | |
| SCHEMBL11078723 | 0.86 | SRD5A2 (0.57) | POLBALDH1A1SRD5A2HPGDLMNA | |
| SCHEMBL9262585 | 0.80 | HTT (0.59) | POLBALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL850542 | 0.80 | SRD5A2 (0.62) | POLBALDH1A1SRD5A2 | |
| SCHEMBL9269526 | 0.79 | POLB (0.56) | POLBSMN1; SMN2SRD5A2MAPTHPGD | |
| SCHEMBL2367221 | 0.79 | POLB (0.56) | POLBALDH1A1MAPTRAB9AKDM4E | |
| SCHEMBL10187426 | 0.79 | POLB (0.45) | POLBALDH1A1SMN1; SMN2SRD5A2MAPT | |
| SCHEMBL9474042 | 0.78 | LTA4H (0.59) | ALDH1A1MMP14GAAHTTHTR2A | |
| SCHEMBL16866569 | 0.77 | POLB (0.54) | POLBALDH1A1SMN1; SMN2SRD5A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5403934-A | Heterocyclic compounds | BURROUGHS WELLCOME CO. (US) | 1995-04-04 | — | — | US | disclosed |
| WO-1991013873-A1 | HETEROCYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-09-19 | — | — | WO | disclosed |
| EP-0447164-A1 | Heterocyclic compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-09-18 | — | — | EP | disclosed |