SCHEMBL9260950

SCHEMBL9260950

C=CCON1C(=O)c2cccc(-c3ccc(Br)cc3)c2C1=O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.60
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
GAA P10253 1/20 0.38
MAPT P10636 2/20 0.35
KDM4E B2RXH2 1/20 0.35
LMNA P02545 1/20 0.35
THRB P10828 1/20 0.35
HPGD P15428 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
POLB P06746 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
ALOX15 P16050 1/20 0.32
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31
ATM Q13315 1/20 0.31
SLC6A3 Q01959 1/20 0.31
GSK3B P49841 1/20 0.31
PTPRC P08575 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1715729 0.76 ALDH1A1 (1.00) ALDH1A1MEN1KMT2AGAAMAPT
SCHEMBL30767916 0.76 ALDH1A1 (1.00) ALDH1A1MEN1KMT2AGAAMAPT
SCHEMBL12415529 0.75 ALDH1A1 (0.66) ALDH1A1MEN1KMT2AGAAHPGD
SCHEMBL8677467 0.73 ALDH1A1 (0.73) ALDH1A1MEN1KMT2AGAAMAPT
SCHEMBL8744384 0.67 ALDH1A1 (0.54) ALDH1A1MEN1KMT2AGAAMAPT
SCHEMBL8744380 0.67 ALDH1A1 (0.54) ALDH1A1MEN1KMT2AGAAMAPT
SCHEMBL7706801 0.65 ALDH1A1 (0.55) ALDH1A1MEN1KMT2AGAAMAPT
SCHEMBL28251781 0.64 TDP1 (0.58) ALDH1A1GAATDP1CYP1A2CYP2C9
SCHEMBL706912 0.63 ALDH1A1 (0.48) ALDH1A1MEN1KMT2AGAAMAPT
SCHEMBL6141672 0.63 ALDH1A1 (0.66) ALDH1A1MEN1KMT2AGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5378677-A Applying with cyclohexenone derivative BASF AKTIENGESELLSCHAFT (DE) 1995-01-03 US disclosed