Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5954013 | 0.77 | LMNA (0.50) | LMNAKMT2AAKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL247637 | 0.75 | LMNA (0.49) | LMNAKMT2AAKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL1400599 | 0.75 | CTSA (0.39) | AKR1C3AKR1C2ALDH1A1GAAAKR1C1 | |
| SCHEMBL1551107 | 0.74 | KMT2A (0.56) | LMNAKMT2AALDH1A1GAAMAPT | |
| SCHEMBL11868268 | 0.74 | LMNA (0.47) | LMNAKMT2AALDH1A1GAAPOLB | |
| SCHEMBL11389555 | 0.74 | LMNA (0.47) | LMNAKMT2AALDH1A1GAAPOLB | |
| SCHEMBL9988882 | 0.73 | LMNA (0.51) | LMNAKMT2AALDH1A1GAAPOLB | |
| SCHEMBL2436440 | 0.72 | AKR1C3 (0.36) | AKR1C3AKR1C2AKR1C1PTGS1KCNQ2 | |
| SCHEMBL5470596 | 0.72 | LMNA (0.40) | LMNAKMT2AALDH1A1GAAMAPT | |
| SCHEMBL21381538 | 0.71 | AKR1C3 (0.37) | LMNAKMT2AAKR1C3AKR1C2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5466690-A | Treating psoriasis | ALLERGAN, INC. (US) | 1995-11-14 | — | — | US | disclosed |
| US-5354776-A | Treating psoriasis | ALLERGAN, INC. (US) | 1994-10-11 | — | — | US | disclosed |
| EP-0284261-B1 | Acetylenes disubstituted with a heteroaromatic group and a tetralin group having retinoid like activity | ALLERGAN INC (US) | 1994-01-05 | — | — | EP | disclosed |
| US-5246962-A | Psoriasis, skin disorders | ALLERGAN, INC. (US) | 1993-09-21 | — | — | US | disclosed |
| US-5149705-A | Treatment of psoriasis | ALLERGAN, INC. (US) | 1992-09-22 | — | — | US | disclosed |
| EP-0284261-A1 | Acetylenes disubstituted with a heteroaromatic group and a tetralin group having retinoid like activity | ALLERGAN, INC (US) | 1988-09-28 | — | — | EP | disclosed |