Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LAP3 | P28838 | 2/20 | 0.33 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4938951 | 0.72 | CYP2C19 (0.46) | LMNAKMT2AMMP9MMP8MMP13 | |
| SCHEMBL9260962 | 0.72 | LMNA (0.46) | LMNAKMT2AMAPTPANK3ALDH1A1 | |
| SCHEMBL675017 | 0.72 | MMP9 (0.56) | LMNAKMT2AMMP9MMP8MMP13 | |
| SCHEMBL9395046 | 0.72 | MMP9 (0.56) | LMNAKMT2AMMP9MMP8MMP13 | |
| SCHEMBL18248588 | 0.71 | CYP2C19 (0.45) | LMNAKMT2AMMP9MMP8MMP13 | |
| SCHEMBL18248622 | 0.71 | CYP2C19 (0.45) | LMNAKMT2AMMP9MMP8MMP13 | |
| SCHEMBL1849342 | 0.71 | ATM (0.39) | LMNAKMT2AMMP9MMP8MMP13 | |
| SCHEMBL18248539 | 0.71 | PPARG (0.41) | LMNAKMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL18248615 | 0.71 | PPARG (0.41) | LMNAKMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL5450890 | 0.71 | ALDH1A1 (0.46) | LMNAKMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271181-B2 | Inhibitors of p38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-09-18 | — | — | US | disclosed |
| EP-1392300-A1 | 2,5-DISUBSTITUTED PYRIDINE, PYRIMIDINE, PYRIDAZINE AND 1, 2, 4-TRIAZINE DERIVATIVES FOR USE AS P38 INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2004-03-03 | — | — | EP | disclosed |
| US-20030096817-A1 | Inhibitors of p38 | VERTEX PHARMACEUTICALS INCORPORATED | 2003-05-22 | — | — | US | disclosed |
| WO-2002092087-A1 | 2,5-DISUBSTITUTED PYRIDINE, PYRIMIDINE, PYRIDAZINE AND 1, 2, 4-TRIAZINE DERIVATIVES FOR USE AS P38 INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030096817-A1 | Inhibitors of p38 | MAPK1, MAPK3, MAP3K1 | LMNA 2007/4885KMT2A 3956/4885MMP9 940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.