SCHEMBL9261

SCHEMBL9261

O=[C]OC(c1ccccc1)[N+](=O)[O-]

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSR P00390 1/20 0.40
ALDH1A1 P00352 4/20 0.35
LMNA P02545 1/20 0.35
NPC1 O15118 1/20 0.34
ADAM17 P78536 1/20 0.34
KMT2A Q03164 3/20 0.33
NPSR1 Q6W5P4 3/20 0.33
KDM4E B2RXH2 2/20 0.33
MAPT P10636 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
MEN1 O00255 2/20 0.32
ACP3 P15309 1/20 0.32
CYP3A4 P08684 1/20 0.31
MAPK1 P28482 1/20 0.31
APOBEC3G Q9HC16 1/20 0.31
CYP2D6 P10635 2/20 0.31
CYP1A2 P05177 1/20 0.31
PKM P14618 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
GAA P10253 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7480393 1.00 GSR (0.40) GSRALDH1A1LMNANPC1ADAM17
SCHEMBL376375 0.79 GSR (0.44) GSRALDH1A1LMNANPC1ADAM17
SCHEMBL3125882 0.78 GSR (0.41) GSRALDH1A1LMNANPC1ADAM17
SCHEMBL2028620 0.78 GSR (0.43) GSRALDH1A1LMNANPC1ADAM17
SCHEMBL10403262 0.76 GSR (0.55) GSRALDH1A1LMNANPC1ADAM17
SCHEMBL10692142 0.76 GSR (0.46) GSRALDH1A1LMNANPC1ADAM17
SCHEMBL1831576 0.76 GSR (0.42) GSRALDH1A1LMNANPC1ADAM17
SCHEMBL10936620 0.76 GSR (0.42) GSRALDH1A1LMNANPC1ADAM17
SCHEMBL8582412 0.76 GSR (0.42) GSRALDH1A1LMNANPC1ADAM17
SCHEMBL27521461 0.76 GSR (0.46) GSRALDH1A1LMNANPC1ADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3004 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113929748-B Kit for detecting BACE1 enzyme activity and application thereof 中国科学技术大学 2023-10-20 CN claimed
US-20230113948-A1 SYNTHETIC PROCESSES AND INTERMEDIATES ARBUTUS BIOPHARMA CORPORATION (US) 2023-04-13 US claimed
WO-2023049774-A1 GENETICALLY ENCODED AND EXOGENOUSLY TRIGGERED PROTEIN-PROTEIN LIGATION UNIVERSITY OF WASHINGTON (US) 2023-03-30 WO claimed
CN-114846051-A Synthetic methods and intermediates 阿布特斯生物制药公司 2022-08-02 CN claimed
CN-113929748-A Kit for detecting activity of BACE1 enzyme and application 中国科学技术大学 2022-01-14 CN claimed
EP-3053944-B1 METHOD FOR PRODUCING POLYALKYLENE GLYCOL DERIVATIVE HAVING AMINO GROUP AT END, POLYMERIZATION INITIATOR FOR USE IN THE SAME, AND ALCOHOL COMPOUND AS RAW MATERIAL FOR THE POLYMERIZATION INITIATOR SHINETSU CHEMICAL CO (JP) 2021-10-06 EP claimed
CN-108732355-B Detection method for determining activity of BACE1 enzyme-cleaved NRG1 and kit thereof 首都医科大学附属北京安定医院 2021-06-25 CN claimed
WO-2021127214-A1 SYNTHETIC PROCESSES AND INTERMEDIATES ARBUTUS BIOPHARMA CORPORATION (CA) 2021-06-24 WO claimed
CN-110343117-A The preparation method of artemisinin derivative 中国科学院上海药物研究所 2019-10-18 CN claimed
CN-110267958-A Process for preparing pyrazolo [1,5-a ] pyrimidines and salts thereof 阿雷生物药品公司 2019-09-20 CN claimed
EP-0102239-A1 Azetidinone derivatives, a process for their preparation and their use as intermediates in the preparation of carbapenem antibiotics SANKYO COMPANY LIMITED (JP) 1984-03-07 EP claimed
US-4314936-A BY MEASUREM,ENT OF FLUORESENCE YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) 1982-02-09 US claimed
US-4269773-A CEPHALOSPORINS SHIONOGI & CO., LTD. (JP) 1981-05-26 US claimed
US-4180571-A Arylmalonamido-1-oxadethiacephalosporins SHIONOGI & CO., LTD. (JP) 1979-12-25 US claimed
US-4081433-A D-Nle4 -somatostatin and analogues thereof AMERICAN HOME PRODUCTS CORPORATION (US) 1978-03-28 US claimed
US-4061608-A POLYPEPTIDE, INHIBIT SECRETION OF GROWTH HORMONE AMERICAN HOME PRODUCTS CORPORATION (US) 1977-12-06 US claimed
US-4018726-A [D-Phe6 ]-LH-RH and intermediates therefor SCHALLY ANDREW VICTOR 1977-04-19 US claimed
US-4009159-A PENICILLINS FUJISAWA PHARMACEUTICAL CO., LTD. (JA) 1977-02-22 US claimed
US-3998795-A (Acyl-D-α-amino acid-gly-gly-tyr-ala)1 -somatostatin AMERICAN HOME PRODUCTS CORPORATION (US) 1976-12-21 US claimed
US-3931140-A (H-gly-gly-tyr-ala)1 -somatostatin AMERICAN HOME PRODUCTS CORPORATION (US) 1976-01-06 US claimed