SCHEMBL2028620

SCHEMBL2028620

NOC(c1ccccc1)[N+](=O)[O-]

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GSR P00390 1/20 0.43
IDO1 P14902 8/20 0.39
TDO2 P48775 6/20 0.39
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39
KDM4E B2RXH2 2/20 0.39
MAPT P10636 2/20 0.39
NPSR1 Q6W5P4 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
KMT2A Q03164 1/20 0.39
FBP1 P09467 1/20 0.38
IDO2 Q6ZQW0 1/20 0.37
DPP4 P27487 2/20 0.37
F2 P00734 1/20 0.37
NPC1 O15118 1/20 0.37
ADAM17 P78536 1/20 0.37
MAPK1 P28482 1/20 0.37
APOBEC3G Q9HC16 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL376375 0.84 GSR (0.44) GSRALDH1A1LMNAKDM4EMAPT
SCHEMBL10403262 0.81 GSR (0.55) GSRALDH1A1LMNAKDM4EMAPT
SCHEMBL27521461 0.81 GSR (0.46) GSRALDH1A1LMNAKDM4EMAPT
SCHEMBL10936620 0.81 GSR (0.42) GSRALDH1A1LMNAKDM4EMAPT
SCHEMBL8582412 0.81 GSR (0.42) GSRALDH1A1LMNAKDM4EMAPT
SCHEMBL1831576 0.81 GSR (0.42) GSRALDH1A1LMNAKDM4EMAPT
SCHEMBL10692142 0.81 GSR (0.46) GSRALDH1A1LMNAKDM4EMAPT
SCHEMBL3125882 0.79 GSR (0.41) GSRALDH1A1LMNAKDM4EMAPT
SCHEMBL7117066 0.79 KDM4E (0.44) GSRALDH1A1LMNAKDM4EMAPT
SCHEMBL38107 0.79 NPSR1 (0.43) GSRALDH1A1LMNAMAPTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140274903-A1 USE OF GALACTOSE OXIDASE FOR SELECTIVE CHEMICAL CONJUGATION OF PROTRACTOR MOLECULES TO PROTEINS OF THERAPEUTIC INTEREST NOVO NORDISK HEALTHCARE AG (CH) 2014-09-18 US disclosed
US-20110170075-A1 DEVICE FOR CHEMICAL AND BIOCHEMICAL REACTIONS USING PHOTO-GENERATED REAGENTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2011-07-14 US disclosed
EP-2332645-A1 Apparatus for chemical and biochemical reactions using photo-generated reagents THE UNIVERSITY OF HOUSTON (US) 2011-06-15 EP disclosed
US-7838466-B2 Device for chemical and biochemical reactions using photo-generated reagents THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2010-11-23 US disclosed
US-20100028939-A1 Use of Galactose Oxidase for Selective Chemical Conjugation of Protractor Molecules to Proteins of Therapeutic Interest NOVO NORDISK HEALTHCARE A/G (CH) 2010-02-04 US disclosed
US-7544638-B2 Device for chemical and biochemical reactions using photo-generated reagents THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2009-06-09 US disclosed
US-7491680-B2 Device for chemical and biochemical reactions using photo-generated reagents THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2009-02-17 US disclosed
US-20080318806-A1 DEVICE FOR CHEMICAL AND BIOCHEMICAL REACTIONS USING PHOTO-GENERATED REAGENTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2008-12-25 US disclosed
US-20080248971-A1 METHOD FOR PROVIDING MICROARRAYS INVITROGEN CORPORATION (US) 2008-10-09 US disclosed
US-20060198819-A1 Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest NOVO NORDISK HEALTHCARE A/G (CH) 2006-09-07 US disclosed
US-20040035690-A1 Method and apparatus for chemical and biochemical reactions using photo-generated reagents THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2004-02-26 US disclosed
US-20040023368-A1 Apparatus for light controlled parallel synthesis of molecular sequence arrays on solid surfaces THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2004-02-05 US disclosed
US-20030186427-A1 Apparatus for selectively converting photogenerated reagent precursors to photogenerated reagents associated with parallel synthesis of molecular sequence arrays on solid surfaces THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2003-10-02 US disclosed
US-20030143131-A1 For parallel synthesis of molecular sequence arrays on solid surfaces THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2003-07-31 US disclosed
EP-1054726-B1 APPARATUS FOR CHEMICAL AND BIOCHEMICAL REACTIONS USING PHOTO-GENERATED REAGENTS UNIV HOUSTON OFFICE OF TECHNOL (US) 2003-07-30 EP disclosed
EP-1258288-A2 Method and apparatus for chemical and biochemical reactions using photo-generated reagents THE UNIVERSITY OF HOUSTON (US) 2002-11-20 EP disclosed
US-6426184-B1 MAKING MULTIMERS SUCH AS DNA OR PEPTIDES IN CHEMICAL REACTOR BY SOLUTION-BASED PHOTOCHEMICAL REACTIONS INVOLVING REAGENTS GENERATED IN SITU BY IRRADIATION THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2002-07-30 US disclosed
US-20020081582-A1 Making multimers such as DNA or peptides in chemical reactor by solution-based photochemical reactions involving reagents generated in situ by irradiation REGENTS OF THE UNIVERSITY OF MICHIGAN, THE 2002-06-27 US disclosed
EP-1054726-A2 METHOD AND APPARATUS FOR CHEMICAL AND BIOCHEMICAL REACTIONS USING PHOTO-GENERATED REAGENTS THE UNIVERSITY OF HOUSTON (US) 2000-11-29 EP disclosed
WO-1999041007-A2 METHOD AND APPARATUS FOR CHEMICAL AND BIOCHEMICAL REACTIONS USING PHOTO-GENERATED REAGENTS UNIVERSITY OF HOUSTON (US) 1999-08-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060198819-A1 Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest GALE, GALNT2, GALNT1 GSR 924/4885IDO1 2467/4885TDO2 217/4885
US-20040035690-A1 Method and apparatus for chemical and biochemical reactions using photo-generated reagents PPOX, LIG4, AOX1 GSR 298/4885IDO1 3309/4885TDO2 1427/4885
US-20140274903-A1 USE OF GALACTOSE OXIDASE FOR SELECTIVE CHEMICAL CONJUGATION OF PROTRACTOR MOLECULES TO PROTEINS OF THERAPEUTIC INTEREST GALE, GALNT2, GALNT1 GSR 924/4885IDO1 2467/4885TDO2 217/4885
US-20100028939-A1 Use of Galactose Oxidase for Selective Chemical Conjugation of Protractor Molecules to Proteins of Therapeutic Interest GALE, GALNT2, GALNT1 GSR 924/4885IDO1 2467/4885TDO2 217/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.