Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8657548 | 0.88 | MEN1 (0.46) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL19921303 | 0.86 | NOTUM (0.43) | ALDH1A1MAPTRAB9ANOTUMRXFP1 | |
| SCHEMBL1614271 | 0.84 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL9256636 | 0.83 | NPC1 (0.44) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL8447552 | 0.73 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL8655802 | 0.72 | MAPT (0.44) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL3150583 | 0.72 | KDM4E (0.47) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL8653533 | 0.70 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL8328343 | 0.69 | ALDH1A1 (0.45) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL8657721 | 0.68 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | disclosed |