Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.80 |
| ▸ | HPGD | P15428 | 3/20 | 0.80 |
| ▸ | RAB9A | P51151 | 3/20 | 0.80 |
| ▸ | NPC1 | O15118 | 2/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.80 |
| ▸ | HTT | P42858 | 1/20 | 0.80 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.67 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | ATM | Q13315 | 1/20 | 0.66 |
| ▸ | MMP13 | P45452 | 5/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL862913 | 0.91 | KDM4E (0.74) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL5841102 | 0.89 | KDM4E (0.72) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL3031260 | 0.89 | KDM4E (0.72) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL75327 | 0.89 | KDM4E (1.00) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL7380603 | 0.89 | ALOX15 (0.68) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL2769403 | 0.88 | KDM4E (0.70) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL31370745 | 0.88 | KDM4E (0.74) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL4815909 | 0.88 | KDM4E (0.74) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL5842371 | 0.87 | KDM4E (0.69) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL13173588 | 0.87 | KDM4E (0.73) | KDM4EALDH1A1HPGDRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | disclosed |