Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9262404 | 1.00 | POLB (0.55) | POLBKDM4EADRB2ADRB1LMNA | |
| SCHEMBL9262399 | 1.00 | POLB (0.55) | POLBKDM4EADRB2ADRB1LMNA | |
| SCHEMBL10553168 | 0.86 | STAT3 (0.57) | POLBKDM4EADRB2ADRB1LMNA | |
| SCHEMBL27432980 | 0.81 | KDM4E (0.66) | POLBKDM4EADRB2ALDH1A1ATM | |
| Hydrochloric Acid SCHEMBL9782076 | 0.81 | SLC2A1 (0.65) | POLBKDM4EADRB2ALDH1A1CYP3A4 | |
| SCHEMBL9829336 | 0.81 | POLB (0.53) | POLBKDM4EATMMAPTKMT2A | |
| SCHEMBL11432643 | 0.80 | ADRB2 (0.57) | KDM4EADRB2ADRB1LMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL9829893 | 0.80 | POLB (0.51) | POLBKDM4EATMMAPTKMT2A | |
| SCHEMBL11811971 | 0.79 | SLC2A1 (0.68) | POLBKDM4EADRB2ALDH1A1CYP3A4 | |
| SCHEMBL9700731 | 0.78 | ADRB2 (0.66) | KDM4EADRB2ADRB1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5405866-A | Administering with cytostatic drugs to treat drug resistant tumors | HOFFMANN-LA ROCHE INC. (US) | 1995-04-11 | — | — | US | disclosed |
| US-5302727-A | For use with antitumor agents | HOFFMANN-LA ROCHE INC. (US) | 1994-04-12 | — | — | US | disclosed |
| EP-0523493-A1 | Dithianes | F. HOFFMANN-LA ROCHE AG (CH) | 1993-01-20 | — | — | EP | disclosed |