Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 9/20 | 0.66 |
| ▸ | ADRB1 | P08588 | 8/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | ADRB3 | P13945 | 7/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | OXTR | P30559 | 1/20 | 0.63 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9700569 | 1.00 | ADRB2 (0.66) | ADRB2ADRB1LMNASLC6A4SLC6A3 | |
| Sulfuric Acid SCHEMBL10570655 | 0.94 | ADRB3 (0.62) | ADRB2ADRB1LMNASLC6A4SLC6A3 | |
| SCHEMBL10553168 | 0.92 | STAT3 (0.57) | ADRB2ADRB1LMNASLC6A4SLC6A3 | |
| SCHEMBL11498377 | 0.91 | KMT2A (0.57) | ADRB2ADRB1LMNASLC6A4SLC6A3 | |
| SCHEMBL11202332 | 0.87 | ADRB2 (0.64) | ADRB2ADRB1LMNASLC6A4SLC6A3 | |
| SCHEMBL11429165 | 0.87 | ADRB2 (0.65) | ADRB2ADRB1LMNASLC6A4SLC6A3 | |
| SCHEMBL7308971 | 0.87 | KMT2A (0.65) | ADRB2ADRB1LMNASLC6A4SLC6A3 | |
| SCHEMBL10674081 | 0.85 | ADRB2 (0.62) | ADRB2ADRB1LMNASLC6A4SLC6A3 | |
| SCHEMBL11432735 | 0.84 | CA12 (0.48) | ADRB2ADRB1LMNASLC6A4SLC6A3 | |
| SCHEMBL1970148 | 0.82 | ADRB2 (0.64) | ADRB2ADRB1LMNASLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5082939-A | Pyridazine derivatives | I.S.F. SOCIETA PER AZIONI (IT) | 1992-01-21 | — | — | US | disclosed |
| US-4873328-A | Process for preparing alkoxyalkylidenehydrazinopyridazine derivatives | I.S.F. SOCIETA PER AZIONI (IT) | 1989-10-10 | — | — | US | disclosed |
| US-4853383-A | β-blocking substituted imidazoles | MERCK & CO., INC. (US) | 1989-08-01 | — | — | US | disclosed |
| EP-0274409-A2 | Process for preparing alkoxyalkyl-idenehydrazinopyridazine derivatives | I.S.F. Socièta per Azioni (IT) | 1988-07-13 | — | — | EP | disclosed |
| US-4642311-A | β-adrenergic blocking imidazolylphenoxy propanolamines | MERCK & CO., INC. (US) | 1987-02-10 | — | — | US | disclosed |
| US-4567276-A | HYPOTENSIVE AGENTS, ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4440774-A | ANTIHYPERTENSIVE AGENTS AND B-ANDRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1984-04-03 | — | — | US | disclosed |