Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.34 |
| ▸ | CSNK2A3 | Q8NEV1 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10388579 | 0.93 | MAPT (0.41) | MAPTTSHRTDP1HSD11B1KDM4E | |
| SCHEMBL7455602 | 0.84 | ALDH1A1 (0.43) | MAPTTSHRHSD11B1KDM4EMEN1 | |
| SCHEMBL11448924 | 0.77 | HSD11B1 (0.53) | TSHRTDP1HSD11B1KDM4EMEN1 | |
| SCHEMBL9460144 | 0.72 | MAPT (0.48) | MAPTTSHRTDP1KDM4EMEN1 | |
| SCHEMBL4487085 | 0.70 | MAPT (0.63) | MAPTTSHRTDP1KDM4EMEN1 | |
| SCHEMBL398824 | 0.65 | PDE4A (0.42) | MAPTTSHRKDM4EMEN1KMT2A | |
| SCHEMBL11697413 | 0.64 | TSHR (0.53) | MAPTTSHRTDP1KDM4EMEN1 | |
| SCHEMBL31295166 | 0.64 | KMT2A (0.39) | MAPTTSHRMEN1KMT2ACSNK2A2 | |
| SCHEMBL13788796 | 0.62 | PDE4A (0.40) | MAPTTSHRKDM4EMEN1KMT2A | |
| SCHEMBL2032325 | 0.58 | ALDH1A1 (0.43) | MAPTTSHRTDP1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428168-A | Substituted butyrolactol ether derivative | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-06-27 | — | — | US | disclosed |