Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 8/20 | 0.56 |
| ▸ | RARB | P10826 | 7/20 | 0.56 |
| ▸ | RARG | P13631 | 7/20 | 0.56 |
| ▸ | RARA | P10276 | 5/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.56 |
| ▸ | CYP26B1 | Q9NR63 | 8/20 | 0.41 |
| ▸ | RXRA | P19793 | 4/20 | 0.39 |
| ▸ | RXRB | P28702 | 3/20 | 0.39 |
| ▸ | RXRG | P48443 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9138829 | 0.85 | CYP26A1 (0.48) | CYP26A1RARBRARGRARACYP3A4 | |
| SCHEMBL6669237 | 0.85 | RARB (0.53) | CYP26A1RARBRARGRARACYP3A4 | |
| SCHEMBL8875222 | 0.82 | RARA (0.39) | CYP26A1RARBRARGRARACYP3A4 | |
| SCHEMBL9270488 | 0.79 | RARB (0.46) | CYP26A1RARBRARGRARACYP3A4 | |
| SCHEMBL9271283 | 0.77 | RARB (0.44) | CYP26A1RARBRARGRARACYP3A4 | |
| SCHEMBL9266634 | 0.77 | CYP26A1 (0.60) | CYP26A1RARBRARGRARACYP3A4 | |
| SCHEMBL6669241 | 0.76 | PRSS1 (0.36) | CYP26A1RARBRARGRARACYP3A4 | |
| SCHEMBL7652311 | 0.76 | RARA (0.41) | CYP26A1RARBRARGRARACYP3A4 | |
| SCHEMBL9269510 | 0.76 | CYP26A1 (0.56) | CYP26A1RARBRARGRARACYP3A4 | |
| SCHEMBL7652315 | 0.76 | CYP26A1 (0.37) | CYP26A1RARBRARGRARACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5466690-A | Treating psoriasis | ALLERGAN, INC. (US) | 1995-11-14 | — | — | US | disclosed |
| US-5354776-A | Treating psoriasis | ALLERGAN, INC. (US) | 1994-10-11 | — | — | US | disclosed |
| US-5246962-A | Psoriasis, skin disorders | ALLERGAN, INC. (US) | 1993-09-21 | — | — | US | disclosed |