Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.46 |
| ▸ | RARG | P13631 | 6/20 | 0.46 |
| ▸ | RARA | P10276 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.46 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GNRHR | P30968 | 1/20 | 0.36 |
| ▸ | CYP26B1 | Q9NR63 | 4/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9271283 | 0.93 | RARB (0.44) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL6666439 | 0.81 | RARA (0.36) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL6668823 | 0.81 | RARB (0.53) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL9271965 | 0.80 | CYP3A4 (0.49) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL9264784 | 0.80 | RARB (0.46) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL9264097 | 0.79 | CYP26A1 (0.56) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL8865169 | 0.78 | KDM4E (0.33) | RARBRARGRARACYP3A4KMT2A | |
| SCHEMBL9257896 | 0.78 | CYP26A1 (0.46) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL9139472 | 0.77 | RARA (0.39) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL9271587 | 0.77 | RARB (0.48) | RARBRARGRARACYP3A4CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5466690-A | Treating psoriasis | ALLERGAN, INC. (US) | 1995-11-14 | — | — | US | disclosed |
| US-5354776-A | Treating psoriasis | ALLERGAN, INC. (US) | 1994-10-11 | — | — | US | disclosed |
| US-5246962-A | Psoriasis, skin disorders | ALLERGAN, INC. (US) | 1993-09-21 | — | — | US | disclosed |
| US-5149705-A | Treatment of psoriasis | ALLERGAN, INC. (US) | 1992-09-22 | — | — | US | disclosed |
| EP-0284261-A1 | Acetylenes disubstituted with a heteroaromatic group and a tetralin group having retinoid like activity | ALLERGAN, INC (US) | 1988-09-28 | — | — | EP | disclosed |