Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9542909 | 0.79 | CYP2C9 (0.36) | TGFBR1SRCSMN1; SMN2CYP2C9MAPT | |
| SCHEMBL9386237 | 0.78 | CYP2C9 (0.36) | TGFBR1SRCSMN1; SMN2CYP2C9MAPT | |
| SCHEMBL5984224 | 0.77 | RAB9A (0.41) | SMN1; SMN2TP53MAPTHTTNPC1 | |
| SCHEMBL8163707 | 0.76 | CYP2C9 (0.43) | TGFBR1SRCCYP2C9MAPTLMNA | |
| SCHEMBL9541742 | 0.75 | CYP2C9 (0.36) | TGFBR1SRCSMN1; SMN2CYP2C9MAPT | |
| SCHEMBL9529094 | 0.75 | CYP2C9 (0.34) | TGFBR1SRCCYP2C9MAPTLMNA | |
| SCHEMBL9543157 | 0.75 | CYP2C9 (0.36) | TGFBR1SRCSMN1; SMN2CYP2C9MAPT | |
| SCHEMBL9232103 | 0.72 | CYP2C9 (0.40) | CYP2C9MAPTHTTNR3C1HPGD | |
| SCHEMBL9232111 | 0.72 | CYP2C9 (0.40) | SRCCYP2C9MAPTLMNANPC1 | |
| SCHEMBL9530345 | 0.72 | CYP2C9 (0.34) | TGFBR1SRCCYP2C9MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430042-A | Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use | AKTIEBOLAGET ASTRA (SE) | 1995-07-04 | — | — | US | disclosed |