Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9180440 | 0.84 | MAPT (0.42) | MAPTUSP2ALOX15TSHRMEN1 | |
| SCHEMBL9266782 | 0.83 | PDE4D (0.54) | MAPTUSP2ALOX15TSHRAGTR1 | |
| SCHEMBL9267049 | 0.82 | PDE4A (0.43) | MAPTTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL9325828 | 0.81 | MAPT (0.47) | MAPTUSP2ALOX15TSHRAGTR1 | |
| SCHEMBL9186261 | 0.80 | PDE4B (0.43) | MAPTUSP2TSHRMEN1KMT2A | |
| SCHEMBL9181892 | 0.80 | MAPT (0.43) | MAPTUSP2ALOX15TSHRMEN1 | |
| SCHEMBL9325121 | 0.78 | AGTR1 (0.42) | MAPTAGTR1MEN1KMT2AALDH1A1 | |
| SCHEMBL9271648 | 0.77 | SMN1; SMN2 (0.43) | MAPTTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL9183215 | 0.74 | SMN1; SMN2 (0.43) | MAPTUSP2TSHRMEN1KMT2A | |
| SCHEMBL9187632 | 0.73 | PDE4D (0.51) | MAPTUSP2ALOX15TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5449676-A | Bronchodilator agents | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1995-09-12 | — | — | US | disclosed |
| EP-0581805-A1 | NOVEL PYRIDAZINES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1994-02-09 | — | — | EP | disclosed |
| WO-1992019602-A1 | NOVEL PYRIDAZINES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1992-11-12 | — | — | WO | disclosed |
| EP-0510562-A1 | Pyridazines | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1992-10-28 | — | — | EP | disclosed |