Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | USP10 | Q14694 | 1/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | USP13 | Q92995 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29648618 | 0.75 | KDM4E (0.49) | HTTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL30393692 | 0.71 | LMNA (0.43) | MAP4K4MAPT | |
| SCHEMBL30277469 | 0.70 | MAOB (0.50) | PARP1ALDH1A1KDM4EGABRG2GABRB3 | |
| SCHEMBL29790789 | 0.67 | EGFR (0.42) | HTTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL9919060 | 0.64 | L3MBTL1 (0.59) | PARP1ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL28674308 | 0.62 | USP10 (0.45) | PARP1CCNCCDK8USP10PIK3C3 | |
| SCHEMBL30106860 | 0.62 | PRKCI (0.42) | — | |
| SCHEMBL19161108 | 0.62 | USP10 (0.49) | PARP1CCNCCDK8USP10PIK3C3 | |
| SCHEMBL18312194 | 0.62 | MAP4K4 (0.74) | MAP4K4 | |
| SCHEMBL3737053 | 0.62 | HTT (0.49) | PARP1CCNCCDK8USP10PIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5387585-A | Treating epilepsy, anxiety, sleep disorders, schizophrnia, senile dementia | HOFFMANN-LA ROCHE INC. (US) | 1995-02-07 | — | — | US | disclosed |
| EP-0519307-A2 | Tetracyclic Imidazodiazepines | F. HOFFMANN-LA ROCHE AG (CH) | 1992-12-23 | — | — | EP | disclosed |