SCHEMBL9268295

SCHEMBL9268295

O=C(O)CCc1c(F)cc(Cl)c(F)c1Cl

nearest known ligand 0.56

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
GPR17 Q13304 10/20 0.56
FFAR1 O14842 5/20 0.46
FFAR4 Q5NUL3 3/20 0.46
FBP1 P09467 1/20 0.39
ACLY P53396 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19522398 0.74 GPR17 (0.55) GPR17FFAR1FFAR4FBP1
SCHEMBL4715895 0.74 FFAR1 (0.59) GPR17FFAR1FFAR4
SCHEMBL27037031 0.74 FFAR1 (0.50) GPR17FFAR1FFAR4
SCHEMBL14739207 0.72 GPR17 (1.00) GPR17FBP1
SCHEMBL2576979 0.72 GPR17 (0.47) GPR17FFAR1FFAR4
SCHEMBL14793754 0.72 FFAR1 (0.57) GPR17FFAR1FFAR4
SCHEMBL25213812 0.71 FFAR1 (0.50) GPR17FFAR1FFAR4
SCHEMBL25219212 0.71 KEAP1 (0.47) FFAR1FFAR4ACLY
SCHEMBL11139559 0.70 KDM4E (0.59) GPR17FFAR1FFAR4
SCHEMBL1590066 0.70 GPR17 (0.57) GPR17FFAR1FFAR4FBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5416096-A 7-(1-pyrrolidinyl)-3-quinolone carboxylic acid derivatives as antibacterial agents and feed additives BAYER AKTIENGESELLSCHAFT (DE) 1995-05-16 US disclosed