Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.43 |
| ▸ | UNG | P13051 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5220639 | 0.84 | HDAC10 (0.49) | HDAC10POLBHDAC8HDAC3HDAC4 | |
| SCHEMBL11296235 | 0.80 | HDAC10 (0.45) | HDAC10HDAC8ALDH1A1KMT2A | |
| SCHEMBL1441399 | 0.79 | HDAC8 (0.47) | HDAC10POLBHDAC8UNGALDH1A1 | |
| SCHEMBL10938419 | 0.78 | HDAC10 (0.55) | HDAC10POLBHDAC8HDAC3HDAC4 | |
| SCHEMBL10939166 | 0.74 | HDAC10 (0.51) | HDAC10POLBHDAC8HDAC3HDAC4 | |
| SCHEMBL10940181 | 0.73 | TSHR (0.55) | HDAC10POLBHDAC8HDAC3HDAC4 | |
| SCHEMBL10938383 | 0.73 | HDAC10 (0.50) | HDAC10POLBSMN1; SMN2KMT2AATM | |
| SCHEMBL5664807 | 0.72 | ATM (0.72) | HDAC10HDAC8HDAC3HDAC4HDAC1 | |
| SCHEMBL20139683 | 0.72 | KMT2A (0.51) | POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL1149847 | 0.71 | CYP2C9 (0.60) | HDAC10POLBHDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995013266-A1 | ACYLPYRROLE-ALKANOIC ACIDS AND INDOLE-2-ALKANOIC ACIDS PLUS THEIR DERIVATIVES FOR USE AS INHIBITORS OF PHOSPHOLIPASE A¿2? | MERCKLE GMBH CHEM.-PHARM. FABRIK (DE) | 1995-05-18 | — | — | WO | disclosed |