Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846349 | 0.91 | MAPT (0.50) | RAB9AMAPTNPC1LOXL2TP53 | |
| SCHEMBL5573693 | 0.83 | MAPT (0.54) | RAB9AMAPTNPC1LOXL2TP53 | |
| SCHEMBL9681875 | 0.81 | MAPT (0.37) | RAB9AMAPTNPC1LOXL2TP53 | |
| SCHEMBL9846167 | 0.80 | MAPT (0.48) | RAB9AMAPTNPC1LOXL2TP53 | |
| SCHEMBL9846394 | 0.79 | MAPT (0.49) | RAB9AMAPTNPC1LOXL2TP53 | |
| SCHEMBL9846184 | 0.78 | MAPT (0.48) | RAB9AMAPTNPC1LOXL2TP53 | |
| SCHEMBL9846193 | 0.78 | MAPT (0.48) | RAB9AMAPTNPC1LOXL2TP53 | |
| SCHEMBL9449230 | 0.76 | MAPT (0.50) | RAB9AMAPTNPC1LOXL2TP53 | |
| SCHEMBL9681865 | 0.74 | C1R (0.39) | RAB9AMAPTNPC1SMN1; SMN2KDM4E | |
| SCHEMBL9846095 | 0.73 | MAPT (0.50) | RAB9AMAPTNPC1LOXL2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5387512-A | Incubating the compound 3-(2-benzoxazol-2-yl-ethyl)-5-ethyl-6-methyl-2-(1H)-pyridinone with liver tissue, oxidation to form a hydroxy group attenching ethyl branch | MERCK & CO. INC. (US) | 1995-02-07 | — | — | US | disclosed |
| US-5387512-A | Incubating the compound 3-(2-benzoxazol-2-yl-ethyl)-5-ethyl-6-methyl-2-(1H)-pyridinone with liver tissue, oxidation to form a hydroxy group attenching ethyl branch | MERCK & CO. INC. (US) | 1995-02-07 | — | — | US | disclosed |
| US-5185251-A | Treatment of HIV and AIDS | MERCK & CO., INC. (US) | 1993-02-09 | — | — | US | disclosed |
| EP-0481802-A1 | Hydroxylated inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | disclosed |
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |