Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 14/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18982990 | 0.79 | SLC6A3 (0.45) | SLC6A3SLC6A2SLC6A4ACHE | |
| SCHEMBL502662 | 0.74 | SLC6A3 (0.37) | SLC6A3SLC6A2SLC6A4ACHE | |
| SCHEMBL8636289 | 0.73 | SLC6A3 (0.53) | SLC6A3SLC6A2SLC6A4ACHE | |
| SCHEMBL4719331 | 0.72 | SLC6A3 (0.42) | SLC6A3SLC6A2SLC6A4ACHE | |
| SCHEMBL757145 | 0.70 | SLC6A3 (0.47) | SLC6A3SLC6A2SLC6A4ACHE | |
| SCHEMBL1958265 | 0.70 | SLC6A3 (0.41) | SLC6A3SLC6A2SLC6A4ACHEMAPT | |
| SCHEMBL6498188 | 0.69 | F2 (0.35) | SLC6A3SLC6A2SLC6A4ACHE | |
| SCHEMBL15876290 | 0.69 | SLC6A3 (0.41) | SLC6A3SLC6A2SLC6A4ACHEALDH1A1 | |
| SCHEMBL2131145 | 0.69 | SLC6A3 (0.53) | SLC6A3SLC6A2SLC6A4ACHE | |
| SCHEMBL29868840 | 0.68 | SLC6A3 (0.49) | SLC6A3SLC6A2SLC6A4ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5453421-A | Aryl and heterocyclic substituted propenamide derivatives | E. R. SQUIBB & SONS, INC. (US) | 1995-09-26 | — | — | US | disclosed |
| EP-0587188-A2 | Aryl and heterocyclic substituted propenamide derivatives | E.R. SQUIBB & SONS, INC. (US) | 1994-03-16 | — | — | EP | disclosed |